RT Journal Article
T1 Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body.
A1 Annese, Valentina
A1 Navarro-Guerrero, Elena
A1 Rodríguez-Prieto, Ismael
A1 Pardal, Ricardo
K1 angiogenesis and neurogenesis
K1 carotid body physiology
K1 hypoxia
K1 neural-crest-derived adult stem cell plasticity and multipotency
AB Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been a matter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxia-released vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11112
UL http://hdl.handle.net/10668/11112
LA en
DS RISalud
RD Apr 10, 2025