RT Generic
T1 Cancer and OSA Beyond Hypoxia Response
A1 Martinez-Garcia, Miguel Angel
A1 Campos-Rodriguez, Francisco
A1 Barbe, Ferran
K1 Tumor-associated macrophages
K1 Sleep-apnea
K1 Links
AB At the outset, we wish to thank Dr Marvisi1 for his interest in our article. As the authors of the letter have stated, in the past few years some outstanding research groups have described other pathophysiological pathways linking OSA with cancer , some orchestrated by hypoxia2-5 and some by sleep fragmentation .2-4,6,7 Some of these pathways are related to alterations to the  immune system in macrophages / monocytes , natural killer cells , lymphocytes , and other immune cells .2-7 Interesting studies and reviews of the role of microvesicles/ exosomes and the impact on the sympathetic/catecholaminergic system and other pathophysiological pathways have recently been published.2-4,8 For this reason, we decided to focus our review on clinical studies in humans that deal with the relationship between OSA and cancer incidence and mortality .9 In fact, we only outlined some basic ideas about pathophysiology in the introductory paragraph of the review , and the last paragraph was dedicated to the limitations of the clinical studies. We encourage the authors to read the excellent revisions made by Gozal et al2-4 for further information, one of which was recently published in  CHEST .
PB Amer coll chest physicians
SN 0012-3692
YR 2016
FD 2016-12-01
LK https://hdl.handle.net/10668/27918
UL https://hdl.handle.net/10668/27918
LA en
NO Martínez-García MÁ, Campos-Rodriguez F, Barbé F. Response. Chest. 2016 Dec;150(6):1412.
DS RISalud
RD Apr 5, 2025