RT Journal Article
T1 Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus.
A1 García-Fontana, Beatriz
A1 Morales-Santana, Sonia
A1 Longobardo, Victoria
A1 Reyes-García, Rebeca
A1 Rozas-Moreno, Pedro
A1 García-Salcedo, José Antonio
A1 Muñoz-Torres, Manuel
K1 Cardiovascular disease
K1 Type 2 diabetes mellitus
K1 Proinflammation
K1 Oxidative stress
K1 Proteomic
K1 Antioxidantes
K1 Biomarcadores
K1 Enfermedades cardiovasculares
K1 Cromatografía liquida
K1 Diabetes mellitus tipo 2
K1 Humanos
K1 Electroforesis bidimensional diferencial en gel
K1 Estrés oxidativo
K1 Proteómica
K1 Espectrometría de masa por láser de matriz asistida de ionización desorción
K1 Espectrometría de masas en tándem
AB Type 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology of these complications is complex and incompletely known in this population. The aim of this study was to compare the serum proteome of patients with type 2 diabetes mellitus presenting or not presenting cardiovascular disease with non-diabetic subjects to find essential proteins related to these cardiovascular complications. This cross-sectional study compares the serum proteome by a combination of protein depletion with 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. The proteins differentially expressed were identified by MALDI TOF/TOF (Matrix-assisted laser desorption/ionization and Time-Of-Flight ion detector) or LC-MS/MS (Liquid Chromatography coupled to Mass-Mass Spectrometry). Type 2 diabetes mellitus patients with cardiovascular disease showed higher expression of plasma retinol binding protein and glutathione peroxidase-3 compared to those without cardiovascular disease and non-diabetic controls. These results show that proteins related to the inflammatory and redox state appear to play an important role in the pathogenesis of the cardiovascular disease in the type 2 diabetes mellitus patients.
PB MDPI
YR 2015
FD 2015-04-27
LK http://hdl.handle.net/10668/2482
UL http://hdl.handle.net/10668/2482
LA spa
NO García-Fontana B, Morales-Santana S, Longobardo V, Reyes-García R, Rozas-Moreno P, García-Salcedo JA, et al. Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus. Int J Mol Sci. 2015; 16(5):9469-83
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 12, 2025