TY  - JOUR
AU  - Moreno-Gonzalez, Ines
AU  - Edwards III, George A.
AU  - Hasan, Omar
AU  - Gamez, Nazaret
AU  - Schulz, Jonathan E.
AU  - Fernandez-Valenzuela, Juan Jose
AU  - Gutierrez, Antonia
AU  - Soto, Claudio
AU  - Schulz, Paul E.
PY  - 2021
DO  - 10.3390/diagnostics11101874
UR  - http://hdl.handle.net/10668/4483
T2  - Diagnostics
AB  - Several common and debilitating neurodegenerative disorders are characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein. In Alzheimer's disease (AD), NFTs are accompanied...
LA  - en
PB  - MDPI
KW  - PET imaging
KW  - Tau
KW  - THK5351
KW  - Tracer
KW  - Biomarker
KW  - Histological assessment
KW  - Cognitive impairment
KW  - Tauopathy
KW  - Alzheimer’s disease
KW  - Dementia
KW  - Tomografía por emisión de positrones
KW  - Proteínas tau
KW  - Trazadores radiactivos
KW  - Biomarcadores
KW  - Técnicas histológicas
KW  - Disfunción cognitiva
KW  - Tauopatías
KW  - Enfermedad de Alzheimer
KW  - Demencia
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Frontotemporal Lobar Degeneration::Frontotemporal Dementia
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Gliosis
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Cytoskeleton::Neurofibrils::Neurofibrillary Tangles
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Supranuclear Palsy, Progressive
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cytoskeletal Proteins::Microtubule Proteins::Microtubule-Associated Proteins::tau Proteins
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, Emission-Computed::Positron-Emission...
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography, Emission-Computed::Positron-Emission Tomography
KW  - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Isotopes::Radioisotopes::Radioactive Tracers
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia
TI  - Longitudinal Assessment of Tau-Associated Pathology by 18F-THK5351 PET Imaging: A Histological, Biochemical, and Behavioral Study
TY  - research article
ER  -