RT Generic
T1 Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines
A1 El-Hammadi, Mazen M.
A1 Arias, Jose L.
K1 active drug targeting
K1 ligand-mediated targeting
K1 nanoparticle
K1 passive drug targeting
K1 PLGA
K1 stealth coating
K1 surface functionalization
K1 Poly(lactic-co-glycolic acid) nanoparticles
K1 Cell-penetrating peptides
K1 Drug-delivery
K1 In-vitro
K1 Polymeric nanoparticles
K1 Poly(ethylene glycol)
K1 Polyethylene-glycol
K1 Mediated delivery
K1 Peg nanoparticles
K1 Targeted delivery
AB Therapeutics are habitually characterized by short plasma half-lives and little affinity for targeted cells. To overcome these challenges, nanoparticulate systems have entered into the disease arena. Poly( D,L-lactide-co-glycolide) (PLGA) is one of the most relevant biocompatible materials to construct drug nanocarriers. Understanding the physical chemistry of this copolymer and current knowledge of its biological fate will help in engineering efficient PLGA-based nanomedicines. Surface modification of the nanoparticle structure has been proposed as a required functionalization to optimize the performance in biological systems and to localize the PLGA colloid into the site of action. In this review, a background is provided on the properties and biodegradation of the copolymer. Methods to formulate PLGA nanoparticles, as well as their in vitro performance and in vivo fate, are briefly discussed. In addition, a special focus is placed on the analysis of current research in the use of surface modification strategies to engineer PLGA nanoparticles, i.e., PEGylation and the use of PEG alternatives, surfactants and lipids to improve in vitro and in vivo stability and to create hydrophilic shells or stealth protection for the nanoparticle. Finally, an update on the use of ligands to decorate the surface of PLGA nanomedicines is included in the review.
PB MDPI AG
YR 2022
FD 2022-01-11
LK http://hdl.handle.net/10668/21442
UL http://hdl.handle.net/10668/21442
LA en
NO El-Hammadi MM, Arias JL. Recent Advances in the Surface Functionalization of PLGA-Based Nanomedicines. Nanomaterials (Basel). 2022 Jan 22;12(3):354.
DS RISalud
RD Apr 7, 2025