RT Journal Article
T1 Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
A1 Trubetskoy, Vassily
A1 Pardiñas, Antonio F
A1 Qi, Ting
A1 Panagiotaropoulou, Georgia
A1 Awasthi, Swapnil
A1 Bigdeli, Tim B
A1 Bryois, Julien
A1 Chen, Chia-Yen
A1 Dennison, Charlotte A
A1 Hall, Lynsey S
A1 Lam, Max
A1 Watanabe, Kyoko
A1 Frei, Oleksandr
A1 Ge, Tian
A1 Harwood, Janet C
A1 Koopmans, Frank
A1 Magnusson, Sigurdur
A1 Richards, Alexander L
A1 Sidorenko, Julia
A1 Wu, Yang
A1 Zeng, Jian
A1 Grove, Jakob
A1 Kim, Minsoo
A1 Li, Zhiqiang
A1 Voloudakis, Georgios
A1 Zhang, Wen
A1 Adams, Mark
A1 Agartz, Ingrid
A1 Atkinson, Elizabeth G
A1 Agerbo, Esben
A1 Al Eissa, Mariam
A1 Albus, Margot
A1 Alexander, Madeline
A1 Alizadeh, Behrooz Z
A1 Alptekin, Köksal
A1 Als, Thomas D
A1 Amin, Farooq
A1 Arolt, Volker
A1 Arrojo, Manuel
A1 Athanasiu, Lavinia
A1 Azevedo, Maria Helena
A1 Bacanu, Silviu A
A1 Bass, Nicholas J
A1 Begemann, Martin
A1 Belliveau, Richard A
A1 Bene, Judit
A1 Benyamin, Beben
A1 Bergen, Sarah E
A1 Blasi, Giuseppe
A1 Bobes, Julio
A1 Bonassi, Stefano
A1 Braun, Alice
A1 Bressan, Rodrigo Affonseca
A1 Bromet, Evelyn J
A1 Bruggeman, Richard
A1 Buckley, Peter F
A1 Buckner, Randy L
A1 Bybjerg-Grauholm, Jonas
A1 Cahn, Wiepke
A1 Cairns, Murray J
A1 Calkins, Monica E
A1 Carr, Vaughan J
A1 Castle, David
A1 Catts, Stanley V
A1 Chambert, Kimberley D
A1 Chan, Raymond C K
A1 Chaumette, Boris
A1 Cheng, Wei
A1 Cheung, Eric F C
A1 Chong, Siow Ann
A1 Cohen, David
A1 Consoli, Angèle
A1 Cordeiro, Quirino
A1 Costas, Javier
A1 Curtis, Charles
A1 Davidson, Michael
A1 Davis, Kenneth L
A1 de Haan, Lieuwe
A1 Degenhardt, Franziska
A1 DeLisi, Lynn E
A1 Demontis, Ditte
A1 Dickerson, Faith
A1 Dikeos, Dimitris
A1 Dinan, Timothy
A1 Djurovic, Srdjan
A1 Duan, Jubao
A1 Ducci, Giuseppe
A1 Dudbridge, Frank
A1 Eriksson, Johan G
A1 Fañanás, Lourdes
A1 Faraone, Stephen V
A1 Fiorentino, Alessia
A1 Forstner, Andreas
A1 Frank, Josef
A1 Freimer, Nelson B
A1 Fromer, Menachem
A1 Frustaci, Alessandra
A1 Gadelha, Ary
A1 Genovese, Giulio
A1 Gershon, Elliot S
A1 Giannitelli, Marianna
A1 Giegling, Ina
A1 Giusti-Rodríguez, Paola
A1 Godard, Stephanie
A1 Goldstein, Jacqueline I
A1 González Peñas, Javier
A1 González-Pinto, Ana
A1 Gopal, Srihari
A1 Gratten, Jacob
A1 Green, Michael F
A1 Greenwood, Tiffany A
A1 Guillin, Olivier
A1 Gülöksüz, Sinan
A1 Gur, Raquel E
A1 Gur, Ruben C
A1 Gutiérrez, Blanca
A1 Hahn, Eric
A1 Hakonarson, Hakon
A1 Haroutunian, Vahram
A1 Hartmann, Annette M
A1 Harvey, Carol
A1 Hayward, Caroline
A1 Henskens, Frans A
A1 Herms, Stefan
A1 Hoffmann, Per
A1 Howrigan, Daniel P
A1 Ikeda, Masashi
A1 Iyegbe, Conrad
A1 Joa, Inge
A1 Julià, Antonio
A1 Kähler, Anna K
A1 Kam-Thong, Tony
A1 Kamatani, Yoichiro
A1 Karachanak-Yankova, Sena
A1 Kebir, Oussama
A1 Keller, Matthew C
A1 Kelly, Brian J
A1 Khrunin, Andrey
A1 Kim, Sung-Wan
A1 Klovins, Janis
A1 Kondratiev, Nikolay
A1 Konte, Bettina
A1 Kraft, Julia
A1 Kubo, Michiaki
A1 Kučinskas, Vaidutis
A1 Kučinskiene, Zita Ausrele
A1 Kusumawardhani, Agung
A1 Kuzelova-Ptackova, Hana
A1 Landi, Stefano
A1 Lazzeroni, Laura C
A1 Lee, Phil H
A1 Legge, Sophie E
A1 Lehrer, Douglas S
A1 Lencer, Rebecca
A1 Lerer, Bernard
A1 Li, Miaoxin
A1 Lieberman, Jeffrey
A1 Light, Gregory A
A1 Limborska, Svetlana
A1 Liu, Chih-Min
A1 Lönnqvist, Jouko
A1 Loughland, Carmel M
A1 Lubinski, Jan
A1 Luykx, Jurjen J
A1 Lynham, Amy
A1 Macek, Milan
A1 Mackinnon, Andrew
A1 Magnusson, Patrik K E
A1 Maher, Brion S
A1 Maier, Wolfgang
A1 Malaspina, Dolores
A1 Mallet, Jacques
A1 Marder, Stephen R
A1 Marsal, Sara
A1 Martin, Alicia R
A1 Martorell, Lourdes
A1 Mattheisen, Manuel
A1 McCarley, Robert W
A1 McDonald, Colm
A1 McGrath, John J
A1 Medeiros, Helena
A1 Meier, Sandra
A1 Melegh, Bela
A1 Melle, Ingrid
A1 Mesholam-Gately, Raquelle I
A1 Metspalu, Andres
A1 Michie, Patricia T
A1 Milani, Lili
A1 Milanova, Vihra
A1 Mitjans, Marina
A1 Molden, Espen
A1 Molina, Esther
A1 Molto, María Dolores
A1 Mondelli, Valeria
A1 Moreno, Carmen
A1 Morley, Christopher P
A1 Muntané, Gerard
A1 Murphy, Kieran C
A1 Myin-Germeys, Inez
A1 Nenadić, Igor
A1 Nestadt, Gerald
A1 Nikitina-Zake, Liene
A1 Noto, Cristiano
A1 Nuechterlein, Keith H
A1 O'Brien, Niamh Louise
A1 O'Neill, F Anthony
A1 Oh, Sang-Yun
A1 Olincy, Ann
A1 Ota, Vanessa Kiyomi
A1 Pantelis, Christos
A1 Papadimitriou, George N
A1 Parellada, Mara
A1 Paunio, Tiina
A1 Pellegrino, Renata
A1 Periyasamy, Sathish
A1 Perkins, Diana O
A1 Pfuhlmann, Bruno
A1 Pietiläinen, Olli
A1 Pimm, Jonathan
A1 Porteous, David
A1 Powell, John
A1 Quattrone, Diego
A1 Quested, Digby
A1 Radant, Allen D
A1 Rampino, Antonio
A1 Rapaport, Mark H
A1 Rautanen, Anna
A1 Reichenberg, Abraham
A1 Roe, Cheryl
A1 Roffman, Joshua L
A1 Roth, Julian
A1 Rothermundt, Matthias
A1 Rutten, Bart P F
A1 Saker-Delye, Safaa
A1 Salomaa, Veikko
A1 Sanjuan, Julio
A1 Santoro, Marcos Leite
A1 Savitz, Adam
A1 Schall, Ulrich
A1 Scott, Rodney J
A1 Seidman, Larry J
A1 Sharp, Sally Isabel
A1 Shi, Jianxin
A1 Siever, Larry J
A1 Sigurdsson, Engilbert
A1 Sim, Kang
A1 Skarabis, Nora
A1 Slominsky, Petr
A1 So, Hon-Cheong
A1 Sobell, Janet L
A1 Söderman, Erik
A1 Stain, Helen J
A1 Steen, Nils Eiel
A1 Steixner-Kumar, Agnes A
A1 Stögmann, Elisabeth
A1 Stone, William S
A1 Straub, Richard E
A1 Streit, Fabian
A1 Strengman, Eric
A1 Stroup, T Scott
A1 Subramaniam, Mythily
A1 Sugar, Catherine A
A1 Suvisaari, Jaana
A1 Svrakic, Dragan M
A1 Swerdlow, Neal R
A1 Szatkiewicz, Jin P
A1 Ta, Thi Minh Tam
A1 Takahashi, Atsushi
A1 Terao, Chikashi
A1 Thibaut, Florence
A1 Toncheva, Draga
A1 Tooney, Paul A
A1 Torretta, Silvia
A1 Tosato, Sarah
A1 Tura, Gian Battista
A1 Turetsky, Bruce I
A1 Üçok, Alp
A1 Vaaler, Arne
A1 van Amelsvoort, Therese
A1 van Winkel, Ruud
A1 Veijola, Juha
A1 Waddington, John
A1 Walter, Henrik
A1 Waterreus, Anna
A1 Webb, Bradley T
A1 Weiser, Mark
A1 Williams, Nigel M
A1 Witt, Stephanie H
A1 Wormley, Brandon K
A1 Wu, Jing Qin
A1 Xu, Zhida
A1 Yolken, Robert
A1 Zai, Clement C
A1 Zhou, Wei
A1 Zhu, Feng
A1 Zimprich, Fritz
A1 Atbaşoğlu, Eşref Cem
A1 Ayub, Muhammad
A1 Benner, Christian
A1 Bertolino, Alessandro
A1 Black, Donald W
A1 Bray, Nicholas J
A1 Breen, Gerome
A1 Buccola, Nancy G
A1 Byerley, William F
A1 Chen, Wei J
A1 Cloninger, C Robert
A1 Crespo-Facorro, Benedicto
A1 Donohoe, Gary
A1 Freedman, Robert
A1 Galletly, Cherrie
A1 Gandal, Michael J
A1 Gennarelli, Massimo
A1 Hougaard, David M
A1 Hwu, Hai-Gwo
A1 Jablensky, Assen V
A1 McCarroll, Steven A
A1 Moran, Jennifer L
A1 Mors, Ole
A1 Mortensen, Preben B
A1 Müller-Myhsok, Bertram
A1 Neil, Amanda L
A1 Nordentoft, Merete
A1 Pato, Michele T
A1 Petryshen, Tracey L
A1 Pirinen, Matti
A1 Pulver, Ann E
A1 Schulze, Thomas G
A1 Silverman, Jeremy M
A1 Smoller, Jordan W
A1 Stahl, Eli A
A1 Tsuang, Debby W
A1 Vilella, Elisabet
A1 Wang, Shi-Heng
A1 Xu, Shuhua
A1 Indonesia Schizophrenia Consortium, 
A1 PsychENCODE, 
A1 Psychosis Endophenotypes International Consortium, 
A1 SynGO Consortium, 
A1 Adolfsson, Rolf
A1 Arango, Celso
A1 Baune, Bernhard T
A1 Belangero, Sintia Iole
A1 Børglum, Anders D
A1 Braff, David
A1 Bramon, Elvira
A1 Buxbaum, Joseph D
A1 Campion, Dominique
A1 Cervilla, Jorge A
A1 Cichon, Sven
A1 Collier, David A
A1 Corvin, Aiden
A1 Curtis, David
A1 Forti, Marta Di
A1 Domenici, Enrico
A1 Ehrenreich, Hannelore
A1 Escott-Price, Valentina
A1 Esko, Tõnu
A1 Fanous, Ayman H
A1 Gareeva, Anna
A1 Gawlik, Micha
A1 Gejman, Pablo V
A1 Gill, Michael
A1 Glatt, Stephen J
A1 Golimbet, Vera
A1 Hong, Kyung Sue
A1 Hultman, Christina M
A1 Hyman, Steven E
A1 Iwata, Nakao
A1 Jönsson, Erik G
A1 Kahn, René S
A1 Kennedy, James L
A1 Khusnutdinova, Elza
A1 Kirov, George
A1 Knowles, James A
A1 Krebs, Marie-Odile
A1 Laurent-Levinson, Claudine
A1 Lee, Jimmy
A1 Lencz, Todd
A1 Levinson, Douglas F
A1 Li, Qingqin S
A1 Liu, Jianjun
A1 Malhotra, Anil K
A1 Malhotra, Dheeraj
A1 McIntosh, Andrew
A1 McQuillin, Andrew
A1 Menezes, Paulo R
A1 Morgan, Vera A
A1 Morris, Derek W
A1 Mowry, Bryan J
A1 Murray, Robin M
A1 Nimgaonkar, Vishwajit
A1 Nöthen, Markus M
A1 Ophoff, Roel A
A1 Paciga, Sara A
A1 Palotie, Aarno
A1 Pato, Carlos N
A1 Qin, Shengying
A1 Rietschel, Marcella
A1 Riley, Brien P
A1 Rivera, Margarita
A1 Rujescu, Dan
A1 Saka, Meram C
A1 Sanders, Alan R
A1 Schwab, Sibylle G
A1 Serretti, Alessandro
A1 Sham, Pak C
A1 Shi, Yongyong
A1 St Clair, David
A1 Stefánsson, Hreinn
A1 Stefansson, Kari
A1 Tsuang, Ming T
A1 van Os, Jim
A1 Vawter, Marquis P
A1 Weinberger, Daniel R
A1 Werge, Thomas
A1 Wildenauer, Dieter B
A1 Yu, Xin
A1 Yue, Weihua
A1 Holmans, Peter A
A1 Pocklington, Andrew J
A1 Roussos, Panos
A1 Vassos, Evangelos
A1 Verhage, Matthijs
A1 Visscher, Peter M
A1 Yang, Jian
A1 Posthuma, Danielle
A1 Andreassen, Ole A
A1 Kendler, Kenneth S
A1 Owen, Michael J
A1 Wray, Naomi R
A1 Daly, Mark J
A1 Huang, Hailiang
A1 Neale, Benjamin M
A1 Sullivan, Patrick F
A1 Ripke, Stephan
A1 Walters, James T R
A1 O'Donovan, Michael C
A1 Schizophrenia Working Group of the Psychiatric Genomics Consortium, 
AB Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.
YR 2022
FD 2022-04-08
LK http://hdl.handle.net/10668/19569
UL http://hdl.handle.net/10668/19569
LA en
DS RISalud
RD Apr 11, 2025