RT Journal Article T1 Premenstrual and menstrual changes reported after COVID-19 vaccination: The EVA project. A1 Baena-Garcia, Laura A1 Aparicio, Virginia A A1 Molina-Lopez, Ana A1 Aranda, Pilar A1 Camara-Roca, Laura A1 Ocon-Hernandez, Olga K1 SARS-CoV-2 K1 fatigue K1 immunization K1 menstrual bleeding K1 menstrual cycle K1 pain AB Menstrual disorders were not reported as a possible secondary effect in any of the clinical trials for the SARS-CoV-2 vaccines. To describe the prevalence of perceived premenstrual and menstrual changes after COVID-19 vaccine administration. Cross-sectional study. A total of 14,153 women (mean age 31.5 ± 9.3 years old) who had received the full course of vaccination at least three months earlier were included in this cross-sectional study. Data including the type of vaccine administered, perceived changes in the amount and duration of menstrual bleeding, presence of clots, cycle length, and premenstrual symptoms were collected through a retrospective online survey from June to September 2021. Of the women who participated in this study, 3136 reported no menstrual changes and 11,017 (78% of the study sample) reported experiencing menstrual cycle changes after vaccination. In summary, women who reported menstrual changes after vaccination were older (overall p  Women vaccinated against COVID-19 usually perceive mild menstrual and premenstrual changes. Future studies are warranted to clarify the physiological mechanisms behind these widely reported changes. PB Sage Publications Ltd. YR 2022 FD 2022-06-16 LK http://hdl.handle.net/10668/20226 UL http://hdl.handle.net/10668/20226 LA en NO Baena-García L, Aparicio VA, Molina-López A, Aranda P, Cámara-Roca L, Ocón-Hernández O. Premenstrual and menstrual changes reported after COVID-19 vaccination: The EVA project. Womens Health (Lond). 2022 Jan-Dec;18:8 DS RISalud RD Apr 6, 2025