RT Journal Article
T1 Decreased STAMP2 expression in association with visceral adipose tissue dysfunction.
A1 Moreno-Navarrete, José María
A1 Ortega, Francisco
A1 Serrano, Marta
A1 Pérez-Pérez, Rafael
A1 Sabater, Mònica
A1 Ricart, Wifredo
A1 Tinahones Madueño, Francisco José
A1 Peral, Belén
A1 Fernández-Real, José Manuel
K1 Membrane Proteins
K1 Thiazolidinediones
K1 Tumor Necrosis Factor-alpha
K1 rosiglitazone
K1 Oxidoreductases
K1 STEAP4 protein, human
K1 Hypoglycemic Agents
AB CONTEXTSix-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice. However, there have been contradictory reports in humans.OBJECTIVEWe aimed to explore STAMP2 in association with inflammatory and metabolic status of human obesity.DESIGN, PATIENTS, AND METHODSSTAMP2 gene expression was analyzed in adipose tissue samples (171 visceral and 67 sc depots) and during human preadipocyte differentiation. Human adipocytes were treated with macrophage-conditioned medium, TNF-α, and rosiglitazone.RESULTSIn visceral adipose tissue, STAMP2 gene expression was significantly decreased in obese subjects, mainly in obese subjects with type 2 diabetes. STAMP2 gene expression and protein were significantly and inversely associated with obesity phenotype measures (body mass index, waist, hip, and fat mass) and obesity-associated metabolic disturbances (systolic blood pressure and fasting glucose). In addition, STAMP2 gene expression was positively associated with lipogenic (FASN, ACC1, SREBP1, THRSP14, TRα, and TRα1), CAV1, IRS1, GLUT4, and CD206 gene expression. In sc adipose tissue, STAMP2 gene expression was not associated with metabolic parameters. In both fat depots, STAMP2 gene expression in stromovascular cells was significantly higher than in mature adipocytes. STAMP2 gene expression was significantly increased during the differentiation process in parallel to adipogenic genes, being increased in preadipocytes derived from lean subjects. Macrophage-conditioned medium (25%) and TNF-α (100 ng/ml) administration increased whereas rosiglitazone (2 μM) decreased significantly STAMP2 gene expression in human differentiated adipocytes.CONCLUSIONSDecreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes.
PB Endocrine Society
SN 0021-972X
YR 2011
FD 2011-11
LK http://hdl.handle.net/10668/705
UL http://hdl.handle.net/10668/705
LA en
NO Moreno-Navarrete JM, Ortega F, Serrano M, Pérez-Pérez R, Sabater M, Ricart W, et al. Decreased STAMP2 expression in association with visceral adipose tissue dysfunction. J. Clin. Endocrinol. Metab.. 2011.96(11):E1816-25
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 7, 2025