%0 Journal Article
%A Erton, Zeynep Belce
%A Sevim, Ecem
%A de Jesús, Guilherme Ramires
%A Cervera, Ricard
%A Ji, Lanlan
%A Pengo, Vittorio
%A Ugarte, Amaia
%A Andrade, Danieli
%A Andreoli, Laura
%A Atsumi, Tatsuya
%A Fortin, Paul R
%A Gerosa, Maria
%A Zuo, Yu
%A Petri, Michelle
%A Sciascia, Savino
%A Tektonidou, Maria G
%A Aguirre-Zamorano, Maria Angeles
%A Branch, D Ware
%A Erkan, Doruk
%A APS ACTION
%T Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry').
%D 2022
%@ 2053-8790
%U http://hdl.handle.net/10668/20164
%X To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry. We identified persistently aPL-positive patients recorded as 'pregnant' during prospective follow-up, and defined 'aPL-related outcome' as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment. Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss  In our multicentre, international, aPL-positive cohort, of 55 first pregnancies observed prospectively, 15 (27%) were complicated by early pregnancy loss. Of the remaining 40 pregnancies, composite pregnancy morbidity was observed in 9 (23%) pregnancies.
%K antibodies, anticardiolipin
%K antibodies, antiphospholipid
%K antiphospholipid syndrome
%~