RT Journal Article
T1 Development and Challenges in Animal Tuberculosis Vaccination
A1 Balseiro, Ana
A1 Thomas, Jobin
A1 Gortázar, Christian
A1 Risalde, María A.
K1 Vaccination
K1 Tuberculosis
K1 Bacillus Calmette–Guérin (BCG)
K1 Heat-inactivated mycobacterium bovis vaccine (HIMB)
K1 Domestic animal
K1 Wildlife
K1 Vacunación
K1 Mycobacterium bovis
K1 Vacuna BCG
K1 Animales domésticos
K1 Animales salvajes
K1 Refugio de fauna
AB Vaccination with Bacillus Calmette-Guérin (BCG) constituted a major advance in the prevention of human tuberculosis (TB) in the beginning of the past century. BCG has also a clear potential for use in animals and, in particular, in the main domestic species subjected to TB control programs, cattle. Nowadays, the use of BCG vaccination against TB in cattle is not permitted by European Union legislation because BCG can induce a cellular immune response producing diagnostic interference in the eradication programs based on tuberculin single and comparative intradermal tests imposed worldwide. In this review we recall the history of TB vaccination as well as different vaccine trials and the response to vaccination in both domestic and wild animals. Promising potential inactivated vaccines are also reviewed. Research studies are mainly focused to improve vaccine efficacy, and at the same time to ensure its easy administration, safety and stability in the environment. Great challenges remain, particularly in terms of vaccine candidates and also in the acceptance of vaccination. Vaccination should be included in a strategic plan for integrated control of TB under a "one health" perspective, which also includes other measures such as improved biosafety on farms to avoid or decrease contact between domestic and wild animals or control of wildlife reservoirs to avoid overabundance that may favor infection maintenance.
PB MDPI
YR 2020
FD 2020-06-15
LK http://hdl.handle.net/10668/3650
UL http://hdl.handle.net/10668/3650
LA en
NO Balseiro A, Thomas J, Gortázar C, Risalde MA. Development and Challenges in Animal Tuberculosis Vaccination. Pathogens. 2020 Jun 15;9(6):472
DS RISalud
RD Apr 7, 2025