RT Journal Article
T1 Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.
A1 Everson, Todd M
A1 Vives-Usano, Marta
A1 Seyve, Emie
A1 Cardenas, Andres
A1 Lacasaña, Marina
A1 Craig, Jeffrey M
A1 Lesseur, Corina
A1 Baker, Emily R
A1 Fernandez-Jimenez, Nora
A1 Heude, Barbara
A1 Perron, Patrice
A1 Gónzalez-Alzaga, Beatriz
A1 Halliday, Jane
A1 Deyssenroth, Maya A
A1 Karagas, Margaret R
A1 Íñiguez, Carmen
A1 Bouchard, Luigi
A1 Carmona-Sáez, Pedro
A1 Loke, Yuk J
A1 Hao, Ke
A1 Belmonte, Thalia
A1 Charles, Marie A
A1 Martorell-Marugán, Jordi
A1 Muggli, Evelyne
A1 Chen, Jia
A1 Fernández, Mariana F
A1 Tost, Jorg
A1 Gómez-Martín, Antonio
A1 London, Stephanie J
A1 Sunyer, Jordi
A1 Marsit, Carmen J
A1 Lepeule, Johanna
A1 Hivert, Marie-France
A1 Bustamante, Mariona
AB Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
YR 2021
FD 2021-08-24
LK http://hdl.handle.net/10668/18407
UL http://hdl.handle.net/10668/18407
LA en
DS RISalud
RD Apr 7, 2025