RT Journal Article T1 Ankle Osteoarthritis Aetiology. A1 Herrera-Pérez, Mario A1 González-Martín, David A1 Vallejo-Márquez, Mercedes A1 Godoy-Santos, Alexandre L A1 Valderrabano, Victor A1 Tejero, Sergio K1 ankle cartilage K1 ankle fractures K1 ankle osteoarthritis K1 etiology AB Ankle osteoarthritis affects 1% of the population and, unlike gonarthrosis or coxarthrosis, is secondary to previous trauma in more than 75% of cases. Another peculiarity of this disease is that it affects a younger and active population, with socio-occupational implications. Mechanical factors, such as incongruity, instability, malalignment, and impacts, which increase stress on isolated areas of the ankle cartilage, have been clearly associated with the development of osteoarthritis. However, we cannot ignore the importance of pro-inflammatory mediators present from the moment of fracture as triggers of the cascade that eventually causes chondrocyte cell death, ultimately responsible for ankle osteoarthritis. SN 2077-0383 YR 2021 FD 2021-09-29 LK https://hdl.handle.net/10668/27358 UL https://hdl.handle.net/10668/27358 LA en DS RISalud RD Apr 11, 2025