RT Journal Article
T1 Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial.
A1 Camacho-Barcia, María L
A1 Bulló, Mònica
A1 Garcia-Gavilán, Jesús F
A1 Ruiz-Canela, Miguel
A1 Corella, Dolores
A1 Estruch, Ramón
A1 Fitó, Montserrat
A1 García-Layana, Alfredo
A1 Arós, Fernando
A1 Fiol, Miquel
A1 Lapetra, José
A1 Serra-Majem, Lluis
A1 Pintó, Xavier
A1 García-Arellano, Ana
A1 Vinyoles, Ernest
A1 Sorli, José Vicente
A1 Salas-Salvadó, Jordi
AB Cataract, one of the most frequent causes of blindness in developed countries, is strongly associated with aging. The exact mechanisms underlying cataract formation are still unclear, but growing evidence suggests a potential role of inflammatory and oxidative processes. Therefore, antioxidant and anti-inflammatory factors of the diet, such as vitamin K1, could play a protective role. To examine the association between dietary vitamin K1 intake and the risk of incident cataracts in an elderly Mediterranean population. A prospective analysis was conducted in 5860 participants from the Prevención con Dieta Mediterránea Study, a randomized clinical trial executed between 2003 and 2011. Participants were community-dwelling men (44.2%) and women (55.8%), and the mean (SD) age was 66.3 (6.1) years. Dietary vitamin K1 intake was evaluated using a validated food frequency questionnaire. The time to the cataract event was calculated as the time between recruitment and the date of the occurrence to cataract surgery, the time to the last visit of the follow-up, date of death, or the end of the study. Hazard ratios and 95% CIs for cataract incidence were estimated with a multivariable Cox proportional hazards model. Participants were community-dwelling men (44.2%; n = 868) and women (55.8%; n = 1086), and the mean (SD) age was 66.3 (6.1) years. After a median of 5.6 years follow-up, we documented a total of 768 new cataracts. Participants in the highest tertile of dietary vitamin K1 intake had a lower risk of cataracts than those in the lowest tertile (hazard ratio, 0.71; 95% CI, 0.58-0.88; P = .002), after adjusting for potential confounders. High intake of dietary vitamin K1 was associated with a reduced risk of cataracts in an elderly Mediterranean population even after adjusting by other potential confounders. isrctn.org: ISRCTN35739639.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11189
UL http://hdl.handle.net/10668/11189
LA en
DS RISalud
RD Apr 7, 2025