RT Journal Article
T1 Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
A1 van Duijnhoven, Fränzel J B
A1 Jenab, Mazda
A1 Hveem, Kristian
A1 Siersema, Peter D
A1 Fedirko, Veronika
A1 Duell, Eric J
A1 Kampman, Ellen
A1 Halfweeg, Anouk
A1 van Kranen, Henk J
A1 van den Ouweland, Jody M W
A1 Weiderpass, Elisabete
A1 Murphy, Neil
A1 Langhammer, Arnulf
A1 Ness-Jensen, Eivind
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Cadeau, Claire
A1 Kvaskoff, Marina
A1 Boutron-Ruault, Marie-Christine
A1 Katzke, Verena A
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Kotanidou, Anastasia
A1 Kritikou, Maria
A1 Palli, Domenico
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Matullo, Giuseppe
A1 Peeters, Petra
A1 Brustad, Magritt
A1 Olsen, Karina Standahl
A1 Lasheras, Cristina
A1 Obón-Santacana, Mireia
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Chirlaque, Maria-Dolores
A1 Barricarte, Aurelio
A1 Manjer, Jonas
A1 Almquist, Martin
A1 Renström, Frida
A1 Ye, Weimin
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Bradbury, Kathryn E
A1 Freisling, Heinz
A1 Aune, Dagfinn
A1 Norat, Teresa
A1 Riboli, Elio
A1 Bueno-de-Mesquita, H B As
K1 cancer epidemiology
K1 nested case-control study
K1 pancreatic cancer
K1 vitamin D
AB Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
YR 2017
FD 2017-11-22
LK http://hdl.handle.net/10668/11778
UL http://hdl.handle.net/10668/11778
LA en
DS RISalud
RD Apr 17, 2025