%0 Journal Article
%A van Duijnhoven, Fränzel J B
%A Jenab, Mazda
%A Hveem, Kristian
%A Siersema, Peter D
%A Fedirko, Veronika
%A Duell, Eric J
%A Kampman, Ellen
%A Halfweeg, Anouk
%A van Kranen, Henk J
%A van den Ouweland, Jody M W
%A Weiderpass, Elisabete
%A Murphy, Neil
%A Langhammer, Arnulf
%A Ness-Jensen, Eivind
%A Olsen, Anja
%A Tjønneland, Anne
%A Overvad, Kim
%A Cadeau, Claire
%A Kvaskoff, Marina
%A Boutron-Ruault, Marie-Christine
%A Katzke, Verena A
%A Kühn, Tilman
%A Boeing, Heiner
%A Trichopoulou, Antonia
%A Kotanidou, Anastasia
%A Kritikou, Maria
%A Palli, Domenico
%A Agnoli, Claudia
%A Tumino, Rosario
%A Panico, Salvatore
%A Matullo, Giuseppe
%A Peeters, Petra
%A Brustad, Magritt
%A Olsen, Karina Standahl
%A Lasheras, Cristina
%A Obón-Santacana, Mireia
%A Sanchez-Perez, Maria-Jose
%A Dorronsoro, Miren
%A Chirlaque, Maria-Dolores
%A Barricarte, Aurelio
%A Manjer, Jonas
%A Almquist, Martin
%A Renström, Frida
%A Ye, Weimin
%A Wareham, Nick
%A Khaw, Kay-Tee
%A Bradbury, Kathryn E
%A Freisling, Heinz
%A Aune, Dagfinn
%A Norat, Teresa
%A Riboli, Elio
%A Bueno-de-Mesquita, H B As
%T Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
%D 2017
%U http://hdl.handle.net/10668/11778
%X Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
%K cancer epidemiology
%K nested case-control study
%K pancreatic cancer
%K vitamin D
%~