TY - JOUR AU - Lizak, Nathaniel AU - Lugaresi, Alessandra AU - Alroughani, Raed AU - Lechner-Scott, Jeannette AU - Slee, Mark AU - Havrdova, Eva AU - Horakova, Dana AU - Trojano, Maria AU - Izquierdo, Guillermo AU - Duquette, Pierre AU - Girard, Marc AU - Prat, Alexandre AU - Grammond, Pierre AU - Hupperts, Raymond AU - Grand'Maison, Francois AU - Sola, Patrizia AU - Pucci, Eugenio AU - Bergamaschi, Roberto AU - Oreja-Guevara, Celia AU - Van Pesch, Vincent AU - Ramo, Cristina AU - Spitaleri, Daniele AU - Iuliano, Gerardo AU - Boz, Cavit AU - Granella, Franco AU - Olascoaga, Javier AU - Verheul, Freek AU - Rozsa, Csilla AU - Cristiano, Edgardo AU - Flechter, Shlomo AU - Hodgkinson, Suzanne AU - Amato, Maria Pia AU - Deri, Norma AU - Jokubaitis, Vilija AU - Spelman, Tim AU - Butzkueven, Helmut AU - Kalincik, Tomas AU - MSBase Study Group PY - 2016 DO - 10.1136/jnnp-2016-313976 UR - http://hdl.handle.net/10668/10485 T2 - Journal of neurology, neurosurgery, and psychiatry AB - To evaluate variability and predictability of disability trajectories in moderately advanced and advanced multiple sclerosis (MS), and their modifiability with immunomodulatory therapy. The epochs between Expanded Disability Status Scale (EDSS) steps... LA - en KW - Cohort Studies KW - Disability Evaluation KW - Disabled Persons KW - Disease Progression KW - Female KW - Humans KW - Immunomodulation KW - Male KW - Multiple Sclerosis, Relapsing-Remitting TI - Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis. TY - research article VL - 88 ER -