RT Journal Article
T1 An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
A1 Ibañez, Lourdes
A1 Oberfield, Sharon E
A1 Witchel, Selma
A1 Auchus, Richard J
A1 Chang, R Jeffrey
A1 Codner, Ethel
A1 Dabadghao, Preeti
A1 Darendeliler, Feyza
A1 Elbarbary, Nancy Samir
A1 Gambineri, Alessandra
A1 Garcia Rudaz, Cecilia
A1 Hoeger, Kathleen M
A1 Lopez-Bermejo, Abel
A1 Ong, Ken
A1 Peña, Alexia S
A1 Reinehr, Thomas
A1 Santoro, Nicola
A1 Tena-Sempere, Manuel
A1 Tao, Rachel
A1 Yildiz, Bulent O
A1 Alkhayyat, Haya
A1 Deeb, Asma
A1 Joel, Dipesalema
A1 Horikawa, Reiko
A1 de Zegher, Francis
A1 Lee, Peter A
K1 Anti-androgen
K1 Hirsutism
K1 Hyperinsulinism
K1 Insulin sensitizers
K1 Menstrual irregularities
K1 Obesity
K1 Polycystic ovarian morphology
AB This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)1. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Appropriate diagnosis of adolescent PCOS should include adequate and careful evaluation of symptoms, such as hirsutism, severe acne, and menstrual irregularities 2 years beyond menarche, and elevated androgen levels. Polycystic ovarian morphology on ultrasound without hyperandrogenism or menstrual irregularities should not be used to diagnose adolescent PCOS. Hyperinsulinemia, insulin resistance, and obesity may be present in adolescents with PCOS, but are not considered to be diagnostic criteria. Treatment of adolescent PCOS should include lifestyle intervention, local therapies, and medications. Insulin sensitizers like metformin and oral contraceptive pills provide short-term benefits on PCOS symptoms. There are limited data on anti-androgens and combined therapies showing additive/synergistic actions for adolescents. Reproductive aspects and transition should be taken into account when managing adolescents.
PB S. Karger
YR 2017
FD 2017-07-10
LK http://hdl.handle.net/10668/11819
UL http://hdl.handle.net/10668/11819
LA en
NO Ibáñez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, et al. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. Horm Res Paediatr. 2017;88(6):371-395
DS RISalud
RD Apr 18, 2025