TY - JOUR AU - Cebrian, Arancha AU - Gomez-Del-Pulgar, Teresa AU - Mendez-Vidal, Maria Jose AU - Gonzalvez, Maria Luisa AU - Lainez, Nuria AU - Castellano, Daniel AU - Garcia-Carbonero, Iciar AU - Esteban, Emilio AU - Saez, Maria Isabel AU - Villatoro, Rosa AU - Suarez, Cristina AU - Carrato, Alfredo AU - Munarriz-Ferrandiz, Javier AU - Basterrechea, Laura AU - Garcia-Alonso, Mirta AU - Gonzalez-Larriba, Jose Luis AU - Perez-Valderrama, Begoña AU - Cruz-Jurado, Josefina AU - Gonzalez-Del-Alba, Aránzazu AU - Moreno, Fernando AU - Reynes, Gaspar AU - Rodriguez-Remirez, Maria AU - Boni, Valentina AU - Mahillo-Fernandez, Ignacio AU - Martin, Yolanda AU - Viqueira, Andrea AU - Garcia-Foncillas, Jesus PY - 2017 DO - 10.1038/srep41371 UR - http://hdl.handle.net/10668/10802 T2 - Scientific reports AB - Sunitinib is the currently standard treatment for metastatic renal cell carcinoma (mRCC). Multiple candidate predictive biomarkers for sunitinib response have been evaluated but none of them has been implemented in the clinic yet. The aim of this... LA - en PB - Nature Publishing Group KW - Biomarkers, Tumor KW - Carcinoma, Renal Cell KW - Cyclooxygenase 2 KW - Disease-Free Survival KW - Gene Frequency KW - Adult KW - Aged KW - Aged, 80 and over KW - Female KW - Genetic Association Studies KW - Humans KW - Indoles KW - Kaplan-Meier Estimate KW - Kidney Neoplasms KW - Male KW - Middle Aged KW - Models, Genetic KW - Multivariate Analysis KW - Polymorphism, Single Nucleotide KW - Pyrroles KW - Sunitinib KW - Treatment Outcome TI - Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib. TY - research article VL - 7 ER -