RT Journal Article
T1 Congenital cytomegalovirus, parvovirus and enterovirus infection in Mozambican newborns at birth: A cross-sectional survey.
A1 Madrid, Lola
A1 Varo, Rosauro
A1 Maculuve, Sonia
A1 Nhampossa, Tacilta
A1 Muñoz-Almagro, Carmen
A1 Calderón, Enrique J
A1 Esteva, Cristina
A1 Carrilho, Carla
A1 Ismail, Mamudo
A1 Vieites, Begoña
A1 Friaza, Vicente
A1 Lozano-Dominguez, María Del Carmen
A1 Menéndez, Clara
A1 Bassat, Quique
AB Congenital cytomegalovirus (cCMV) infection is the most prevalent congenital infection acquired worldwide, with higher incidence in developing countries and among HIV-exposed children. Less is known regarding vertical transmission of parvovirus B19 (B19V) and enterovirus (EV). We aimed to assess the prevalence of CMV, B19V and EV vertical transmission and compare results of screening of congenital CMV obtained from two different specimens in a semirural Mozambican maternity. A cross sectional study was conducted among pregnant mothers attending Manhiça District Hospital upon delivery. Information on maternal risk factors was ascertained. Dried umbilical cord (DUC) samples were collected in filter paper for CMV, B19V and EV detection by real-time polymerase chain reaction (RT-PCR), and nasopharyngeal aspirates (NPA) to test for CMV by RT-PCR. Maternal blood samples and placental biopsy samples were also obtained to investigate CMV maternal serology, HIV status and immunopathology. From September 2014 to January 2015, 118 mothers/newborn pairs were recruited. Prevalence of maternal HIV infection was 31.4% (37/118). CMV RT-PCR was positive in 3/115 (2.6%) of DUC samples and in 3/96 (6.3%) of NPA samples obtained from neonates. The concordance of the RT-PCR assay through DUC with their correspondent NPA sample was moderate (Kappa = 0.42 and p This study indicates the significant occurrence of vertical transmission of CMV in southern Mozambique. Larger studies are needed to evaluate the true burden, clinical relevance and consequences of congenital infections with such pathogens in resource-constrained settings.
YR 2018
FD 2018-03-14
LK http://hdl.handle.net/10668/12238
UL http://hdl.handle.net/10668/12238
LA en
DS RISalud
RD Apr 12, 2025