RT Journal Article
T1 Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries.
A1 Fiolet, Thibault
A1 Casagrande, Corinne
A1 Nicolas, Geneviève
A1 Horvath, Zsuzsanna
A1 Frenoy, Pauline
A1 Weiderpass, Elisabete
A1 Katzke, Verena
A1 Kaaks, Rudolf
A1 Rodriguez-Barranco, Miguel
A1 Panico, Salvatore
A1 Sacerdote, Carlotta
A1 Manjer, Jonas
A1 Sonestedt, Emily
A1 Grioni, Sara
A1 Agudo, Antonio
A1 Rylander, Charlotta
A1 Haugdahl Nøst, Therese
A1 Skeie, Guri
A1 Tjønneland, Anne
A1 Raaschou-Nielsen, Ole
A1 Ardanaz, Eva
A1 Amiano, Pilar
A1 Dolores Chirlaque Lopez, Maria
A1 Schulze, Matthias B
A1 Wennberg, Maria
A1 Harlid, Sophia
A1 Cairat, Manon
A1 Kvaskoff, Marina
A1 Huybrechts, Inge
A1 Romana Mancini, Francesca
K1 Breast cancer
K1 Diet
K1 Dioxins
K1 PCBs
K1 Persistent pollutants
K1 Polychlorobiphenyls
AB Dioxins and polychlorobiphenyls (PCBs) are persistent organic pollutants that have demonstrated endocrine disrupting properties. Several of these chemicals are carcinogenic and positive associations have been suggested with breast cancer risk. In general population, diet represents the main source of exposure. Associations between dietary intake of 17 dioxins and 35 PCBs and breast cancer were evaluated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries using multivariable Cox regressions. The present study included 318,607 women (mean ± SD age: 50.7 ± 9.7) with 13,241 incident invasive breast cancers and a median follow-up of 14.9 years (IQR = 13.5-16.4). Dietary intake of dioxins and PCBs was assessed combining EPIC food consumption data with food contamination data provided by the European Food Safety Authority. Exposure to dioxins, dioxins + Dioxin-Like-PCBs, Dioxin-Like-PCBs (DL-PCBs), and Non-Dioxin-Like-PCBs (NDL-PCBs) estimated from reported dietary intakes were not associated with breast cancer incidence, with the following hazard ratios (HRs) and 95% confidence intervals for an increment of 1 SD: HRdioxins = 1.00 (0.98 to 1.02), HRdioxins+DL-PCB = 1.01 (0.98 to 1.03), HRDL-PCB = 1.01 (0.98 to 1.03), and HRNDL-PCB = 1.01 (0.99 to 1.03). Results remained unchanged when analyzing intakes as quintile groups, as well as when analyses were run separately per country, or separating breast cancer cases based on estrogen receptor status or after further adjustments on main contributing food groups to PCBs and dioxins intake and nutritional factors. This large European prospective study does not support the hypothesis of an association between dietary intake of dioxins and PCBs and breast cancer risk.
PB Elsevier Ltd
YR 2022
FD 2022-03-24
LK http://hdl.handle.net/10668/22204
UL http://hdl.handle.net/10668/22204
LA en
NO Fiolet T, Casagrande C, Nicolas G, Horvath Z, Frenoy P, Weiderpass E, et al. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries. Environ Int. 2022 May;163:107213.
DS RISalud
RD Apr 6, 2025