TY - JOUR AU - Muñoz-López, Alvaro AU - Romero-Moya, Damià AU - Prieto, Cristina AU - Ramos-Mejía, Verónica AU - Agraz-Doblas, Antonio AU - Varela, Ignacio AU - Buschbeck, Marcus AU - Palau, Anna AU - Carvajal-Vergara, Xonia AU - Giorgetti, Alessandra AU - Ford, Anthony AU - Lako, Majlinda AU - Granada, Isabel AU - Ruiz-Xivillé, Neus AU - Rodríguez-Perales, Sandra AU - Torres-Ruíz, Raul AU - Stam, Ronald W AU - Fuster, Jose Luis AU - Fraga, Mario F AU - Nakanishi, Mahito AU - Cazzaniga, Gianni AU - Bardini, Michela AU - Cobo, Isabel AU - Bayon, Gustavo F AU - Fernandez, Agustin F AU - Bueno, Clara AU - Menendez, Pablo PY - 2016 DO - 10.1016/j.stemcr.2016.08.013 UR - http://hdl.handle.net/10668/10474 T2 - Stem cell reports AB - Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming leukemias is an extremely... LA - en KW - B-ALL KW - DNA methylome KW - MLL-AF4 KW - Sendai virus KW - cancer reprogramming KW - iPSC KW - transcriptome KW - Animals KW - Biomarkers KW - Cell Line, Transformed KW - Cell Line, Tumor KW - Cell Transdifferentiation KW - Cellular Reprogramming KW - Cluster Analysis KW - DNA Methylation KW - Gene Expression KW - Gene Expression Profiling KW - Gene Rearrangement KW - Hematopoietic Stem Cells KW - Heterografts KW - Humans KW - Induced Pluripotent Stem Cells KW - Mice KW - Myeloid Progenitor Cells KW - Myeloid-Lymphoid Leukemia Protein KW - Oncogene Proteins, Fusion KW - Phenotype KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma KW - Precursor Cells, B-Lymphoid KW - Transcriptome KW - Translocation, Genetic TI - Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency. TY - research article VL - 7 ER -