RT Journal Article
T1 High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
A1 San-Juan, Rafael
A1 Viedma, Esther
A1 Chaves, Fernando
A1 Lalueza, Antonio
A1 Fortún, Jesús
A1 Loza, Elena
A1 Pujol, Miquel
A1 Ardanuy, Carmen
A1 Morales, Isabel
A1 de Cueto, Marina
A1 Resino-Foz, Elena
A1 Morales-Cartagena, Alejandra
A1 Rico, Alicia
A1 Romero, María P
A1 Orellana, María Ángeles
A1 López-Medrano, Francisco
A1 Fernández-Ruiz, Mario
A1 Aguado, José María
K1 CRBI
K1 MIC
K1 MSSA
K1 bacteria
K1 Catheter-related bloodstream infection
K1 Complicated bacteremia
K1 Daptomycin
K1 Methicillin-sensitive Staphylococcus aureus
K1 Septic thrombophlebitis
K1 Vancomycin
K1 Bacteriemia
K1 Infecciones relacionadas con catéteres
K1 Daptomicina
K1 Meticilina
K1 Análisis multivariante
K1 Oxacilina
K1 Vancomicina
AB We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011-June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.
PB Centers for Disease Control and Prevention
SN 1080-6040
YR 2016
FD 2016-06
LK http://hdl.handle.net/10668/2534
UL http://hdl.handle.net/10668/2534
LA en
NO San-Juan R, Viedma E, Chaves F, Lalueza A, Fortún J, Loza E, et al. High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus. Emerging Infect Dis. 2016; 22(6):1057-66
NO Journal Article;
DS RISalud
RD Apr 6, 2025