RT Journal Article
T1 The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer.
A1 D'Ambrosi, Silvia
A1 Visser, Allerdien
A1 Antunes-Ferreira, Mafalda
A1 Poutsma, Ankie
A1 Giannoukakos, Stavros
A1 Sol, Nik
A1 Sabrkhany, Siamack
A1 Bahce, Idris
A1 Kuijpers, Marijke J E
A1 Oude Egbrink, Mirjam G A
A1 Griffioen, Arjan W
A1 Best, Myron G
A1 Koppers-Lalic, Danijela
A1 Oudejans, Cees
A1 Würdinger, Thomas
K1 biomarkers
K1 circular RNA
K1 liquid biopsy
K1 non-small cell lung cancer
K1 platelets
AB Tumor-educated Platelets (TEPs) have emerged as rich biosources of cancer-related RNA profiles in liquid biopsies applicable for cancer detection. Although human blood platelets have been found to be enriched in circular RNA (circRNA), no studies have investigated the potential of circRNA as platelet-derived biomarkers for cancer. In this proof-of-concept study, we examine whether the circRNA signature of blood platelets can be used as a liquid biopsy biomarker for the detection of non-small cell lung cancer (NSCLC). We analyzed the total RNA, extracted from the platelet samples collected from NSCLC patients and asymptomatic individuals, using RNA sequencing (RNA-Seq). Identification and quantification of known and novel circRNAs were performed using the accurate CircRNA finder suite (ACFS), followed by the differential transcript expression analysis using a modified version of our thromboSeq software. Out of 4732 detected circRNAs, we identified 411 circRNAs that are significantly (p-value
PB MDPI AG
SN 2072-6694
YR 2021
FD 2021-09-13
LK http://hdl.handle.net/10668/18559
UL http://hdl.handle.net/10668/18559
LA en
NO D'Ambrosi S, Visser A, Antunes-Ferreira M, Poutsma A, Giannoukakos S, Sol N, et al. The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. Cancers (Basel). 2021 Sep 16;13(18):4644.
DS RISalud
RD Apr 8, 2025