RT Journal Article
T1 Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19: A 3-Month Prospective Cohort.
A1 González, Jessica
A1 Benítez, Iván D
A1 Carmona, Paola
A1 Santisteve, Sally
A1 Monge, Aida
A1 Moncusí-Moix, Anna
A1 Gort-Paniello, Clara
A1 Pinilla, Lucía
A1 Carratalá, Amara
A1 Zuil, María
A1 Ferrer, Ricard
A1 Ceccato, Adrián
A1 Fernández, Laia
A1 Motos, Ana
A1 Riera, Jordi
A1 Menéndez, Rosario
A1 Garcia-Gasulla, Dario
A1 Peñuelas, Oscar
A1 Bermejo-Martin, Jesús F
A1 Labarca, Gonzalo
A1 Caballero, Jesus
A1 Torres, Gerard
A1 de Gonzalo-Calvo, David
A1 Torres, Antoni
A1 Barbé, Ferran
A1 CIBERESUCICOVID Project (COV20/00110, ISCIII)
K1 COVID-19
K1 CT abnormalities
K1 ICU
K1 SARS
K1 SARS-CoV-2
K1 lung function
K1 sequelae
AB More than 20% of hospitalized patients with COVID-19 demonstrate ARDS requiring ICU admission. The long-term respiratory sequelae in such patients remain unclear. What are the major long-term pulmonary sequelae in critical patients who survive COVID-19? Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-min walking test [6MWT]), and chest CT imaging. One hundred twenty-five patients admitted to the ICU with ARDS secondary to COVID-19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%) and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median distance in the 6MWT was 400 m (interquartile range, 362-440 m). CT scans showed abnormal results in 70.2% of patients, demonstrating reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT scan showed worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT scan were age and length of invasive mechanical ventilation during the ICU stay. Three months after hospital discharge, pulmonary structural abnormalities and functional impairment are highly prevalent in patients with ARDS secondary to COVID-19 who required an ICU stay. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months after discharge.
YR 2021
FD 2021-03-04
LK https://hdl.handle.net/10668/27919
UL https://hdl.handle.net/10668/27919
LA en
DS RISalud
RD Apr 6, 2025