RT Journal Article
T1 Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study.
A1 Huang, Jiaqi
A1 Zagai, Ulrika
A1 Hallmans, Göran
A1 Nyrén, Olof
A1 Engstrand, Lars
A1 Stolzenberg-Solomon, Rachael
A1 Duell, Eric J
A1 Overvad, Kim
A1 Katzke, Verena A
A1 Kaaks, Rudolf
A1 Jenab, Mazda
A1 Park, Jin Young
A1 Murillo, Raul
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Bamia, Christina
A1 Bradbury, Kathryn E
A1 Riboli, Elio
A1 Aune, Dagfinn
A1 Tsilidis, Konstantinos K
A1 Capellá, Gabriel
A1 Agudo, Antonio
A1 Krogh, Vittorio
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Weiderpass, Elisabete
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Martínez, Begoña
A1 Redondo-Sanchez, Daniel
A1 Chirlaque, Maria-Dolores
A1 Hm Peeters, Petra
A1 Regnér, Sara
A1 Lindkvist, Björn
A1 Naccarati, Alessio
A1 Ardanaz, Eva
A1 Larrañaga, Nerea
A1 Boutron-Ruault, Marie-Christine
A1 Rebours, Vinciane
A1 Barré, Amélie
A1 Bueno-de-Mesquita, H B As
A1 Ye, Weimin
K1 EPIC cohort
K1 H. pylori infection
K1 chronic corpus atrophic gastritis
K1 nested case-control study
K1 pancreatic cancer risk
AB The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction 
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10723
UL http://hdl.handle.net/10668/10723
LA en
DS RISalud
RD Apr 11, 2025