RT Journal Article
T1 The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms.
A1 Benito, Natividad
A1 Mur, Isabel
A1 Ribera, Alba
A1 Soriano, Alex
A1 Rodriguez-Pardo, Dolors
A1 Sorli, Luisa
A1 Cobo, Javier
A1 Fernandez-Sampedro, Marta
A1 Del-Toro, Maria Dolores
A1 Guio, Laura
A1 Praena, Julia
A1 Bahamonde, Alberto
A1 Riera, Melchor
A1 Esteban, Jaime
A1 Baraia-Etxaburu, Josu Mirena
A1 Martinez-Alvarez, Jesus
A1 Jover-Saenz, Alfredo
A1 Dueñas, Carlos
A1 Ramos, Antonio
A1 Sobrino, Beatriz
A1 Euba, Gorane
A1 Morata, Laura
A1 Pigrau, Carles
A1 Horcajada, Juan P
A1 Coll, Pere
A1 Crusi, Xavier
A1 Ariza, Javier
K1 Antimicrobial empirical treatment
K1 Classification schemes for prosthetic joint infections
K1 Microbial etiology
K1 Multidrug-resistant organisms
K1 Prosthetic joint infections
AB The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
PB MPDI
SN 2077-0383
YR 2019
FD 2019-05-13
LK http://hdl.handle.net/10668/13956
UL http://hdl.handle.net/10668/13956
LA en
NO Benito N, Mur I, Ribera A, Soriano A, Rodríguez-Pardo D, Sorlí L, et al. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. J Clin Med. 2019 May 13;8(5):673
NO This work was supported by the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness (grant number PI15/1026) (Co-funded by European Regional Development Fund/European Social Fund "Investing in your future"). REIPI (Spanish Network for Research in Infectious Disease) is supported by the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness, and by the European Development Regional Fund “A way to achieve Europe”.
DS RISalud
RD Jul 7, 2025