RT Journal Article T1 The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. A1 Benito, Natividad A1 Mur, Isabel A1 Ribera, Alba A1 Soriano, Alex A1 Rodriguez-Pardo, Dolors A1 Sorli, Luisa A1 Cobo, Javier A1 Fernandez-Sampedro, Marta A1 Del-Toro, Maria Dolores A1 Guio, Laura A1 Praena, Julia A1 Bahamonde, Alberto A1 Riera, Melchor A1 Esteban, Jaime A1 Baraia-Etxaburu, Josu Mirena A1 Martinez-Alvarez, Jesus A1 Jover-Saenz, Alfredo A1 Dueñas, Carlos A1 Ramos, Antonio A1 Sobrino, Beatriz A1 Euba, Gorane A1 Morata, Laura A1 Pigrau, Carles A1 Horcajada, Juan P A1 Coll, Pere A1 Crusi, Xavier A1 Ariza, Javier K1 Antimicrobial empirical treatment K1 Classification schemes for prosthetic joint infections K1 Microbial etiology K1 Multidrug-resistant organisms K1 Prosthetic joint infections AB The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs. PB MPDI SN 2077-0383 YR 2019 FD 2019-05-13 LK http://hdl.handle.net/10668/13956 UL http://hdl.handle.net/10668/13956 LA en NO Benito N, Mur I, Ribera A, Soriano A, Rodríguez-Pardo D, Sorlí L, et al. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms. J Clin Med. 2019 May 13;8(5):673 NO This work was supported by the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness (grant number PI15/1026) (Co-funded by European Regional Development Fund/European Social Fund "Investing in your future"). REIPI (Spanish Network for Research in Infectious Disease) is supported by the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness, and by the European Development Regional Fund “A way to achieve Europe”. DS RISalud RD Jul 7, 2025