TY  - JOUR
AU  - Simon, Jorge
AU  - Nuñez-García, Maitane
AU  - Fernández-Tussy, Pablo
AU  - Barbier-Torres, Lucía
AU  - Fernández-Ramos, David
AU  - Gómez-Santos, Beatriz
AU  - Buqué, Xabier
AU  - Lopitz-Otsoa, Fernando
AU  - Goikoetxea-Usandizaga, Naroa
AU  - Serrano-Macia, Marina
AU  - Rodriguez-Agudo, Rubén
AU  - Bizkarguenaga, Maider
AU  - Zubiete-Franco, Imanol
AU  - Gutiérrez-de Juan, Virginia
AU  - Cabrera, Diana
AU  - Alonso, Cristina
AU  - Iruzubieta, Paula
AU  - Romero-Gomez, Manuel
AU  - van Liempd, Sebastiaan
AU  - Castro, Azucena
AU  - Nogueiras, Ruben
AU  - Varela-Rey, Marta
AU  - Falcón-Pérez, Juan Manuel
AU  - Villa, Erica
AU  - Crespo, Javier
AU  - Lu, Shelly C
AU  - Mato, Jose M
AU  - Aspichueta, Patricia
AU  - Delgado, Teresa C
AU  - Martínez-Chantar, María Luz
PY  - 2020
DO  - 10.1016/j.cmet.2020.01.013
UR  - http://hdl.handle.net/10668/15143
T2  - Cell metabolism
AB  - Non-alcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatic fat in an inflammatory/fibrotic background. Herein, we show that the hepatic high-activity glutaminase 1 isoform (GLS1) is overexpressed in NASH. Importantly, GLS1...
LA  - en
KW  - GLS1
KW  - GLS2
KW  - NAFLD
KW  - NASH
KW  - TCA cycle
KW  - VLDL
KW  - folate cycle
KW  - glutaminase
KW  - methionine cycle
KW  - phospholipids
KW  - Adult
KW  - Animals
KW  - Choline
KW  - Disease Models, Animal
KW  - Female
KW  - Glutaminase
KW  - Hepatocytes
KW  - Humans
KW  - Lipid Metabolism
KW  - Lipoproteins, VLDL
KW  - Liver
KW  - Male
KW  - Methionine
KW  - Mice, Inbred C57BL
KW  - Non-alcoholic Fatty Liver Disease
KW  - Oxidative Stress
KW  - Phospholipids
KW  - Triglycerides
TI  - Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
TY  - research article
VL  - 31
ER  -