RT Journal Article
T1 The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases
A1 López-Gambero, Antonio J.
A1 Sanjuan, Carlos
A1 Serrano-Castro, Pedro Jesús
A1 Suárez, Juan
A1 Rodríguez de Fonseca, Fernando
K1 Alzheimer’s disease
K1 Psychiatric disease
K1 Depression
K1 Anxiety
K1 Down’s syndrome
K1 Inositol
K1 Nutraceutical
K1 Insulin signaling
K1 Antioxidant
K1 Aging
K1 Enfermedad de Alzheimer
K1 Trastornos mentales
K1 Depresión
K1 Ansiedad
K1 Síndrome de Down
K1 Suplementos dietéticos
K1 Antioxidantes
K1 Envejecimiento
AB Inositols are sugar-like compounds that are widely distributed in nature and are a part of membrane molecules, participating as second messengers in several cell-signaling processes. Isolation and characterization of inositol phosphoglycans containing myo- or d-chiro-inositol have been milestones for understanding the physiological regulation of insulin signaling. Other functions of inositols have been derived from the existence of multiple stereoisomers, which may confer antioxidant properties. In the brain, fluctuation of inositols in extracellular and intracellular compartments regulates neuronal and glial activity. Myo-inositol imbalance is observed in psychiatric diseases and its use shows efficacy for treatment of depression, anxiety, and compulsive disorders. Epi- and scyllo-inositol isomers are capable of stabilizing non-toxic forms of β-amyloid proteins, which are characteristic of Alzheimer's disease and cognitive dementia in Down's syndrome, both associated with brain insulin resistance. However, uncertainties of the intrinsic mechanisms of inositols regarding their biology are still unsolved. This work presents a critical review of inositol actions on insulin signaling, oxidative stress, and endothelial dysfunction, and its potential for either preventing or delaying cognitive impairment in aging and neurodegenerative diseases. The biomedical uses of inositols may represent a paradigm in the industrial approach perspective, which has generated growing interest for two decades, accompanied by clinical trials for Alzheimer's disease.
PB MDPI
YR 2020
FD 2020-08-20
LK http://hdl.handle.net/10668/3618
UL http://hdl.handle.net/10668/3618
LA en
NO López-Gambero AJ, Sanjuan C, Serrano-Castro PJ, Suárez J, Rodríguez de Fonseca F. The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases. Biomedicines. 2020 Aug 20;8(9):295
DS RISalud
RD Apr 8, 2025