RT Journal Article T1 Depression and Cognitive Impairment in a Spanish Sample of Psychoactive Substance Users Receiving Mental Health Care. A1 Luque, Barbara A1 Garcia, Victoriana A1 Tabernero, Carmen K1 Alcohol K1 Cocaine K1 Cognitive impairment K1 Depression K1 Psychoactive substances AB (1) Background: Numerous studies state that the abuse of psychoactive substances produces cognitive, emotional and behavioral disorders. The aim of this study is to analyze the relationship between the consumption of different psychoactive substances with cognitive performance and depression. (2) Methods: The sample was composed of 254 individuals (M = 41.81; SD = 10.74, from 18 to 69; 76% male) who received psychological treatment related to the use of substances. Participants were classified according to the main substance consumed: alcohol (42.9%), cannabis (20.5%), cocaine (15.4%), heroin (13%) and benzodiazepines (8.3%). The Montreal Cognitive Assessment and the Beck's Depression Inventory were administrated. (3) The results indicated no statistically significant differences between levels of depression depending on the substance consumed. Regarding cognitive impairment, it was found that cocaine consumers have the worst level of cognitive impairment, while cannabis consumers have the best level of cognitive functioning. Finally, it was found that participants with severe depression have higher cognitive impairment than those who were diagnosed with moderate depression. (4) Conclusions: Given the high prevalence of depression and cognitive impairment with the abuse of psychoactive substances, early treatment is recommended to avoid a higher cognitive and emotional affectation. PB MDPI SN 2227-9032 YR 2022 FD 2022-05-09 LK http://hdl.handle.net/10668/20994 UL http://hdl.handle.net/10668/20994 LA en NO Luque B, GarcĂ­a V, Tabernero C. Depression and Cognitive Impairment in a Spanish Sample of Psychoactive Substance Users Receiving Mental Health Care. Healthcare (Basel). 2022 May 11;10(5):887 DS RISalud RD Apr 11, 2025