RT Journal Article
T1 Shift Work and Prostate Cancer: An Updated Systematic Review and Meta-Analysis
A1 Rivera-Izquierdo, Mario
A1 Martínez-Ruiz, Virginia
A1 Castillo-Ruiz, Elena Mercedes
A1 Manzaneda-Navío, Miriam
A1 Pérez-Gómez, Beatriz
A1 Jiménez-Moleón, José Juan
K1 Occupational health
K1 Night work
K1 Rotating shift work
K1 Circadian disruption
K1 Heterogeneity analysis
K1 Prostate cancer
K1 Salud laboral
K1 Horario de trabajo por turnos
K1 Neoplasias de la próstata
K1 Revisión sistemática
K1 Metaanálisis
AB The International Agency of Research in Cancer (IARC) has recently confirmed shift work as a type 2A carcinogen. The results presented in published epidemiological studies regarding prostate cancer are inconsistent and the association remains controversial. The aims of this study were: (a) to investigate the possible association between shift work and prostate cancer incidence, identifying possible sources of heterogeneity; and (b) to analyze the potential effect of publication bias. A search for cohort and case-control studies published from January 1980 to November 2019 was conducted. The quality of the articles was assessed using the Newcastle-Ottawa Scale. Pooled OR were calculated using random-effects models. Heterogeneity was evaluated using Cochran's Q test and data were stratified by potential sources of heterogeneity. Publication bias was analyzed. Eighteen studies were included. No association was found between rotating/night-shift work and prostate cancer, pooled OR 1.07 (95%CI 0.99 to 1.15), I2 = 45.7%, p = 0.016. Heterogeneity was eliminated when only cohort studies (pooled OR 1.03; 95%CI 0.96 to 1.10; I2 = 18.9%, p = 0.264) or high-quality studies (pooled OR 0.99; 95%CI 0.89 to 1.08; I2 = 0.0%, p = 0.571) were considered. A publication bias was detected. An association between shift work and prostate cancer cannot be confirmed with the available current data. Future analytical studies assessing more objective homogeneous exposure variables still seem necessary.
PB MDPI
SN 1661-7827
YR 2020
FD 2020-02-19
LK http://hdl.handle.net/10668/3853
UL http://hdl.handle.net/10668/3853
LA en
NO Rivera-Izquierdo M, Martínez-Ruiz V, Castillo-Ruiz EM, Manzaneda-Navío M, Pérez-Gómez B, Jiménez-Moleón JJ. Shift Work and Prostate Cancer: An Updated Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020 Feb 19;17(4):1345
DS RISalud
RD Apr 10, 2025