RT Journal Article
T1 Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity.
A1 Bernabeu-Wittel, Máximo
A1 Gómez-Díaz, Raquel
A1 González-Molina, Álvaro
A1 Vidal-Serrano, Sofía
A1 Díez-Manglano, Jesús
A1 Salgado, Fernando
A1 Soto-Martín, María
A1 Ollero-Baturone, Manuel
A1 On Behalf Of The Proteo Researchers, 
K1 apoptosis
K1 frailty
K1 multimorbidity
K1 oxidative stress
K1 polypathological patients
K1 sarcopenia
K1 telomere length
AB The presence of oxidative stress, telomere shortening, and apoptosis in polypathological patients (PP) with sarcopenia and frailty remains unknown. Multicentric prospective observational study in order to assess oxidative stress markers (catalase, glutathione reductase (GR), total antioxidant capacity to reactive oxygen species (TAC-ROS), and superoxide dismutase (SOD)), absolute telomere length (aTL), and apoptosis (DNA fragmentation) in peripheral blood samples of a hospital-based population of PP. Associations of these biomarkers to sarcopenia, frailty, functional status, and 12-month mortality were analyzed. Of the 444 recruited patients, 97 (21.8%), 278 (62.6%), and 80 (18%) were sarcopenic, frail, or both, respectively. Oxidative stress markers (lower TAC-ROS and higher SOD) were significantly enhanced and aTL significantly shortened in patients with sarcopenia, frailty or both syndromes. No evidence of apoptosis was detected in blood leukocytes of any of the patients. Both oxidative stress markers (GR, p = 0.04) and telomere shortening (p = 0.001) were associated to death risk and to less survival days. Oxidative stress markers and telomere length were enhanced and shortened, respectively, in blood samples of polypathological patients with sarcopenia and/or frailty. Both were associated to decreased survival. They could be useful in the clinical practice to assess vulnerable populations with multimorbidity and of potential interest as therapeutic targets.
SN 2077-0383
YR 2020
FD 2020-08-18
LK https://hdl.handle.net/10668/27520
UL https://hdl.handle.net/10668/27520
LA en
DS RISalud
RD Feb 24, 2025