RT Journal Article
T1 Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.
A1 Fernández, Tahia D
A1 Gómez, Enrique
A1 Doña, Inmaculada
A1 Campo, Paloma
A1 Rondon, Carmen
A1 Gonzalez, Miguel
A1 Gomez, Francisca
A1 Palomares, Francisca
A1 Salas, Maria
A1 Blanca, Miguel
A1 Mayorga, Cristobalina
A1 Torres, Maria J
K1 Alérgenos
K1 Linfocitos B
K1 Desensibilización inmunológica
K1 Inmunoglobulina G
K1 Células plasmáticas
K1 Rinitis alérgica
K1 Linfocitos T
AB Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tolerance. However, although B and plasma-cell subpopulations are two of the most important cellular subtypes involved in allergic reactions, their relation with AIT efficacy remains unelucidated. The objective was to analyze the effects of immunotherapy on different B and plasma-cell subpopulations and whether these changes correlate with the clinical response to the treatment. Although no changes are found in B-cell subpopulations, responder patients show increased levels of memory B-cells even before the beginning of treatment. Changes in plasma-cell subpopulations are found, mainly in circulating inflammatory plasma-cells that could affect the response to the allergen. Moreover, an early increase of specific-IgG4 and IgG4 secreting-cells was found. All these suggest that the determination of the memory B-cells before the initiation of the treatment, and the quantification of IgG4 and IgG4-secreting-cells in the first months of immunotherapy, could serve as markers for the clinical response to treatment.
PB Nature Publishing Group
YR 2015
FD 2015-09-29
LK http://hdl.handle.net/10668/2287
UL http://hdl.handle.net/10668/2287
LA en
NO Fernández TD, Gómez E, Doña I, Campo P, Rondon C, Gonzalez M, et al. Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response. Sci Rep. 2015; 5:14482
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 12, 2025