RT Journal Article
T1 White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study.
A1 Babio, Nancy
A1 Ibarrola-Jurado, Núria
A1 Bulló, Mònica
A1 Martínez-González, Miguel Ángel
A1 Wärnberg, Julia
A1 Salaverría, Itziar
A1 Ortega-Calvo, Manuel
A1 Estruch, Ramón
A1 Serra-Majem, Lluís
A1 Covas, Maria Isabel
A1 Sorli, José Vicente
A1 Salas-Salvadó, Jordi
K1 Enfermedades cardiovasculares
K1 Estudios transversales
K1 Dieta mediterránea
K1 Recuento de leucocitos
K1 Recuento de linfocitos
K1 Síndrome X metabólico
AB BACKGROUNDThe Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS.METHODSParticipants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospective assessment (n = 1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components.RESULTSOf the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend<0.001). This association was also observed for all WBC subtypes, except for basophils. Compared to participants in the lowest quartile, those in the top quartile of leukocyte, neutrophil and lymphocyte count had an increased risk of MetS incidence. Leukocyte and neutrophil count were found to be strongly associated with the MetS components hypertriglyceridemia and low HDL-cholesterol. Likewise, lymphocyte counts were found to be associated with the incidence of the MetS components low HDL-cholesterol and high fasting glucose. An increase in the total WBC during the follow-up was also associated with an increased risk of MetS.CONCLUSIONSTotal WBC counts, and some subtypes, were positively associated with MetS as well as hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, all components of MetS.
PB Public Library of Science
YR 2013
FD 2013-03-19
LK http://hdl.handle.net/10668/2239
UL http://hdl.handle.net/10668/2239
LA en
NO Babio N, Ibarrola-Jurado N, Bulló M, Martínez-González MÁ, Wärnberg J, Salaverría I, et al. White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study. PLoS ONE. 2013; 8(3):e58354
NO Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; TRIAL REGISTRATIONControlled-Trials.comISRCTN35739639.
DS RISalud
RD Apr 12, 2025