RT Journal Article
T1 Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study.
A1 Gallo, Valentina
A1 Vanacore, Nicola
A1 Bueno-de-Mesquita, H Bas
A1 Vermeulen, Roel
A1 Brayne, Carol
A1 Pearce, Neil
A1 Wark, Petra A
A1 Ward, Heather A
A1 Ferrari, Pietro
A1 Jenab, Mazda
A1 Andersen, Peter M
A1 Wennberg, Patrik
A1 Wareham, Nicholas
A1 Katzke, Verena
A1 Kaaks, Rudolf
A1 Weiderpass, Elisabete
A1 Peeters, Petra H
A1 Mattiello, Amalia
A1 Pala, Valeria
A1 Barricante, Aurelio
A1 Chirlaque, Maria-Dolores
A1 Travier, Noémie
A1 Travis, Ruth C
A1 Sanchez-Perez, Maria-Jose
A1 Pessah-Rasmussen, Hélène
A1 Petersson, Jesper
A1 Tjønneland, Anne
A1 Tumino, Rosario
A1 Quiros, Jose Ramon
A1 Trichopoulou, Antonia
A1 Kyrozis, Andreas
A1 Oikonomidou, Despoina
A1 Masala, Giovanna
A1 Sacerdote, Carlotta
A1 Arriola, Larraitz
A1 Boeing, Heiner
A1 Vigl, Matthaeus
A1 Claver-Chapelon, Francoise
A1 Middleton, Lefkos
A1 Riboli, Elio
A1 Vineis, Paolo
K1 Amyotrophic Lateral Sclerosis
K1 BMI
K1 Cohort study
K1 EPIC study
K1 Physical activity
K1 Vigorous physical activity
AB Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33% less likely to die from ALS compared to those inactive: HR = 0.67 (95% CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity.
YR 2016
FD 2016-03-11
LK http://hdl.handle.net/10668/9911
UL http://hdl.handle.net/10668/9911
LA en
DS RISalud
RD Apr 11, 2025