RT Journal Article T1 Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk. A1 Julibert, Alicia A1 Bibiloni, Maria Del Mar A1 Bouzas, Cristina A1 Martinez-Gonzalez, Miguel Angel A1 Salas-Salvado, Jordi A1 Corella, Dolores A1 Zomeño, Maria Dolors A1 Romaguera, Dora A1 Vioque, Jesus A1 Alonso-Gomez, Angel M A1 Wärnberg, Julia A1 Martinez, J Alfredo A1 Serra-Majem, Luis A1 Estruch, Ramon A1 Tinahones, Francisco J A1 Lapetra, Jose A1 Pinto, Xavier A1 Lopez-Miranda, Jose A1 Garcia-Molina, Laura A1 Gaforio, Jose Juan A1 Matia-Martin, Pilar A1 Daimiel, Lidia A1 Martin-Sanchez, Vicente A1 Vidal, Josep A1 Vazquez, Clotilde A1 Ros, Emili A1 Toledo, Estefanía A1 Becerra-Tomas, Nerea A1 Portoles, Olga A1 Perez-Vega, Karla A A1 Fiol, Miquel A1 Torres-Collado, Laura A1 Tojal-Sierra, Lucas A1 Carabaño-Moral, Rosa A1 Abete, Itziar A1 Sanchez-Villegas, Almudena A1 Casas, Rosa A1 Bernal-Lopez, Maria Rosa A1 Santos-Lozano, Jose Manuel A1 Galera, Ana A1 Ugarriza, Lucia A1 Ruiz-Canela, Miguel A1 Babio, Nancy A1 Coltell, Oscar A1 Schröder, Helmut A1 Konieczna, Jadwiga A1 Orozco-Beltran, Domingo A1 Sorto-Sanchez, Carolina A1 Eguaras, Sonia A1 Barrubes, Laura A1 Fito, Montserrat A1 Tur, Josep A K1 Mediterranean diet K1 Cardiovascular disease risk K1 Dietary fat K1 Fat intake K1 Fatty acids AB Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55-75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3-1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia. PB MDPI YR 2019 FD 2019-06-27 LK http://hdl.handle.net/10668/14204 UL http://hdl.handle.net/10668/14204 LA en NO Julibert A, Bibiloni MDM, Bouzas C, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019 Jun 29;11(7):1493 DS RISalud RD Apr 8, 2025