RT Journal Article
T1 TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis
A1 López Gómez, Carlos
A1 Fernández, Oscar
A1 García León, Juan Antonio
A1 Pinto Medel, María Jesús
A1 Oliver Martos, Begoña
A1 Ortega Pinazo, Jesús
A1 Suardíaz, Margarita
A1 García Trujillo, Lucía
A1 Guijarro Castro, Cristina
A1 Benito León, Julián
A1 Prat, Isidro
A1 Varadé, Jezabel
A1 Álvarez-Lafuente, Roberto
A1 Urcelay, Elena
A1 Leyva, Laura
K1 Adolescente
K1 Adulto
K1 Anciano
K1 Estudios de Casos y Controles
K1 Estudios de Cohortes
K1 Susceptibilidad a Enfermedades
K1 Femenino
K1 Genotipo
K1 Humanos
K1 Masculino
K1 Mediana Edad
K1 Multiple Esclerosis
K1 Polimorfismo de Nucleótido Simple
K1 Receptores del Ligando Inductor de Apoptosis Relacionado con TNF
K1 Ligando Inductor de Apoptosis Relacionado con TNF
K1 España
K1 Adulto Joven
AB The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10(-4), OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10(-5), OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS.
PB Public Library of Science
YR 2011
FD 2011-07-21
LK http://hdl.handle.net/10668/489
UL http://hdl.handle.net/10668/489
LA en
NO López-Gómez C, Fernández O, García-León JA, Pinto-Medel MJ, Oliver-Martos B, Ortega-Pinazo J, et al. TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. PLoS One. 2011;6(7):e21766
NO The authors acknowledge the support from Fondo de Investigación Sanitaria & Fondo Europeo de Desarrollo Regional (PS09/01764) and Consejería de Salud de la Junta de Andalucía (SAS07/0231) to LL, and from Consejería de Innovación (P07-CTS-03223) to OF. The authors also thank the “Red Temática de Investigación Cooperativa Red Española de Esclerosis Múltiple REEM (RD07/0060/0019)” and Fundación Española de Esclerosis Múltiple (FEDEM). CLG is a holder of a fellowship from Consejería de Salud de la Junta de Andalucía (PI 0231-2007), MJPM is a holder of a FIS fellowship (PI 05/1878); JAGL and MS are holders of fellowships from Consejería de Innovación de la Junta de Andalucía (P07-0223).
DS RISalud
RD Apr 18, 2025