RT Journal Article
T1 Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish prospective multicenter study (GECMP-CCR)
A1 Hernandez, J.
A1 Molins, L.
A1 Fibla, J. J.
A1 Heras, F.
A1 Embun, R.
A1 Rivas, J. J.
A1 Grp Espanol Metastasis Pulmonares, 
A1 Soc Espanola Neumol & Cirugia Tor, 
K1 lung metastasis
K1 colorectal carcinoma
K1 lobectomy
K1 VATS
K1 wedge resection
K1 pneumonectomy
K1 Lung metastasectomy
K1 Prognostic-factors
K1 Lymphadenectomy
K1 Survival
K1 Impact
AB Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS.Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival when compared with limited pulmonary resection.Data of 522 patients (64.2% men, mean age 64.5 years) who underwent pulmonary resections with curative intent for CRC metastases over a 2-year period were reviewed. All patients were followed for a minimum of 3 years. Disease-specific survival (DSS) and disease-free survival (DFS) were assessed with the Kaplan-Meier method. Factors associated with DSS and DFS were analyzed using a Cox proportional hazards regression model.A total of 394 (75.6%) patients underwent wedge resection, 19 (3.6%) anatomic segmentectomy, 5 (0.9%) lesser resections not described, 100 (19.3%) lobectomy, and 4 (0.8%) pneumonectomy. Accordingly, 104 (19.9%) patients were treated with major anatomic resection and 418 (80.1%) with lesser resection. Operations were carried out with video-assisted thoracoscopic surgery (VATS) in 93 patients. The overall DSS and DFS were 55 and 28.3 months, respectively. Significant differences in DSS and DFS in favor of major resection versus lesser resection (DSS median not reached versus 52.2 months, P = 0.03; DFS median not reached versus 23.9 months, P
PB Oxford univ press
SN 0923-7534
YR 2016
FD 2016-05-01
LK https://hdl.handle.net/10668/24582
UL https://hdl.handle.net/10668/24582
LA en
DS RISalud
RD Apr 12, 2025