RT Journal Article
T1 Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.
A1 Aleksandrova, Krasimira
A1 Jenab, Mazda
A1 Leitzmann, Michael
A1 Bueno-de-Mesquita, Bas
A1 Kaaks, Rudolf
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Lagiou, Pagona
A1 Rinaldi, Sabina
A1 Freisling, Heinz
A1 Carayol, Marion
A1 Pischon, Tobias
A1 Drogan, Dagmar
A1 Weiderpass, Elisabete
A1 Jakszyn, Paula
A1 Overvad, Kim
A1 Dahm, Christina C
A1 Tjønneland, Anne
A1 Bouton-Ruault, Marie-Christine
A1 Kühn, Tilman
A1 Peppa, Eleni
A1 Valanou, Elissavet
A1 La Vecchia, Carlo
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Sacerdote, Carlotta
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 May, Anne
A1 van Vulpen, Jonna
A1 Benjaminsen Borch, Kristin
A1 Oluwafemi Oyeyemi, Sunday
A1 Quirós, J Ramón
A1 Bonet, Catalina
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Navarro, Carmen
A1 Barricarte, Aurelio
A1 van Guelpen, Bethany
A1 Wennberg, Patrik
A1 Key, Timothy J
A1 Khaw, Kay-Tee
A1 Wareham, Nicholas
A1 Assi, Nada
A1 Ward, Heather A
A1 Aune, Dagfinn
A1 Riboli, Elio
A1 Boeing, Heiner
K1 Physical activity
K1 adiposity
K1 biomarkers
K1 colon cancer
K1 mediating factors
AB There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs  Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11678
UL http://hdl.handle.net/10668/11678
LA en
DS RISalud
RD Apr 17, 2025