TY - JOUR AU - Shin, Mi-Kyung AU - Eraso, Candela Caballero AU - Mu, Yun-Ping AU - Gu, Chenjuan AU - Yeung, Bonnie H Y AU - Kim, Lenise J AU - Liu, Xiao-Ru AU - Wu, Zhi-Juan AU - Paudel, Omkar AU - Pichard, Luis E AU - Shirahata, Machiko AU - Tang, Wan-Yee AU - Sham, James S K AU - Polotsky, Vsevolod Y PY - 2019 DO - 10.1161/CIRCRESAHA.119.315338 UR - http://hdl.handle.net/10668/14532 T2 - Circulation research AB - Obesity leads to resistant hypertension and mechanisms are poorly understood, but high plasma levels of leptin have been implicated. Leptin increases blood pressure acting both centrally in the dorsomedial hypothalamus and peripherally. Sites of the... LA - en KW - carotid body KW - hypertension KW - leptin KW - obesity KW - transient receptor potential channels KW - Animals KW - Antihypertensive Agents KW - Blood Pressure KW - Carotid Body KW - Denervation KW - Disease Models, Animal KW - Hypertension KW - Leptin KW - Male KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Obesity KW - Receptors, Leptin KW - Signal Transduction KW - TRPM Cation Channels TI - Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body. TY - research article VL - 125 ER -