RT Journal Article
T1 Transdiagnostic neurocognitive deficits in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: A 1-year follow-up study.
A1 Correa-Ghisays, Patricia
A1 Sánchez-Ortí, Joan Vicent
A1 Balanzá-Martínez, Vicent
A1 Selva-Vera, Gabriel
A1 Vila-Francés, Joan
A1 Magdalena-Benedito, Rafael
A1 Victor, Victor M
A1 Escribano-López, Irene
A1 Hernández-Mijares, Antonio
A1 Vivas-Lalinde, Juliana
A1 San-Martín, Constanza
A1 Crespo-Facorro, Benedicto
A1 Tabarés-Seisdedos, Rafael
K1 Bipolar disorder
K1 Major depressive disorder
K1 Schizophrenia
K1 Transdiagnostic neurocognitive deficits
K1 Type 2 diabetes mellitus
AB Neurocognition impairments are critical factors in patients with major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), and also in those with somatic diseases such as type 2 diabetes mellitus (T2DM). Intriguingly, these severe mental illnesses are associated with an increased co-occurrence of diabetes (direct comorbidity). This study sought to investigate the neurocognition and social functioning across T2DM, MDD, BD, and SZ using a transdiagnostic and longitudinal approach. A total of 165 participants, including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 healthy controls (HC), were assessed twice at a 1-year interval using a comprehensive, integrated test battery on neuropsychological and social functioning. Common neurocognitive impairments in somatic and psychiatric disorders were identified, including deficits in short-term memory and cognitive reserve (p  The initial sample size was small, and high experimental mortality was observed after follow-up for one year. This longitudinal study provides evidence of some possible overlap in neurocognition deficits across somatic and psychiatric diagnostic categories, such as T2DM, MDD, BD, and SZ, which have high comorbidity. This overlap may be a result of shared genetic and environmental etiological factors. The findings open promising avenues for research on transdiagnostic phenotypes of neurocognition in these disorders, in addition to their biological bases.
YR 2021
FD 2021-12-26
LK http://hdl.handle.net/10668/22285
UL http://hdl.handle.net/10668/22285
LA en
DS RISalud
RD Apr 8, 2025