RT Journal Article
T1 Opioid-Induced Constipation in Oncological Patients: New Strategies of Management.
A1 Mesía, Ricard
A1 Virizuela Echaburu, Juan Antonio
A1 Gómez, Jose
A1 Sauri, Tamara
A1 Serrano, Gloria
A1 Pujol, Eduardo
K1 Cancer
K1 Laxatives
K1 Naloxegol
K1 Opioid analgesics
K1 Opioid-induced constipation
K1 Pain
AB Cancer-associated pain has traditionally been treated with opioid analgesics, often in escalating doses. Opioid-induced constipation (OIC) is a common problem associated with chronic use of opioid analgesics. Typical treatment strategies to alleviate constipation are based on dietary changes, exercise, and laxatives. However, laxatives have a nonspecific action and do not target underlying mechanisms of OIC. This article will review prevalent, clinical presentation and recommendations for the treatment of OIC. An independent literature search was carried out by the authors. We reviewed the literature for randomized controlled trials that studied the efficacy of laxatives, naloxone, and naloxegol in treating OIC. Newer strategies addressing the causal pathophysiology of OIC are needed for a more effective assessment and management of OIC. Finally, traditional recommended therapies are appraised and compared with the latest pharmacological developments. Future research should address whether naloxegol is more efficacious by its comparison directly with first-line treatments, including laxatives.
YR 2019
FD 2019-12-19
LK http://hdl.handle.net/10668/14848
UL http://hdl.handle.net/10668/14848
LA en
DS RISalud
RD Apr 19, 2025