RT Journal Article
T1 PTH levels and not serum phosphorus levels are a predictor of the progression of kidney disease in elderly patients with advanced chronic kidney disease.
T2 El nivel de la hormona paratiroidea (PTH) y no el de fósforo sérico es predictor de la progresión de la enfermedad renal en pacientes mayores con enfermedad renal crónica avanzada.
A1 Toapanta Gaibor, Néstor Gabriel
A1 Nava Pérez, Nathasha Carolina
A1 Martínez Echevers, Yeleine
A1 Montes Delgado, Rafael
A1 Guerrero Riscos, María Ángeles
K1 Advanced chronic kidney disease
K1 Ancianos
K1 Bone mineral metabolism
K1 Chronic kidney disease
K1 Elderly patients.
K1 Enfermedad renal crónica
K1 Enfermedad renal crónica avanzada
K1 Fósforo sérico
K1 Metabolismo óseo mineral
K1 Predialysis
K1 Prediálisis
K1 Progresión de enfermedad renal
K1 Progression of kidney disease
K1 Serum phosphorus
AB At present, there is a high incidence of elderly patients with advanced chronic kidney disease (CKD) and it is important to know the long term progression and the factors that influence it. To analyse the progression of advanced CKD in elderly patients and the influence of bone-mineral metabolism. Retrospective study of 125 patients ≥70years of age with CKD stages 4-5 who started follow-up from January 1, 2007 to December 31, 2008, showing the progression of CKD (measured by the slope of the regression line of the estimated glomerular filtration rate [eGFR] by MDRD-4) over 5years. Progression in the entire group (median and 25th and 75th percentiles): -1.15 (-2.8/0.17) ml/min/1.73m2/year, CKD-4: -1.3 (-2.8/0.03) ml/min/1.73m2/year, CKD-5: -1.03 (-3.0/0.8) ml/min/1.73m2/year; the slope of the regression line was positive in 35 patients (28%: CKD does not progress) and negative in 90 patients (72%: CKD progresses). Negative correlation (Spearman) (slower progression): PTH, albumin/Cr ratio and daily Na excretion (all baseline measurements). No correlation with eGFR, serum P, urinary P excretion, protein intake and intake of P (all baseline measurements). In the linear regression analysis (dependent variable: slope of progression): albuminuria and PTH (both at baseline measurements) influenced this variable independently. Logistic regression (progresses vs. does not progress): PTH, albuminuria and eGFR (all at baseline measurements) influenced significantly. In our group of elderly patients, impairment of renal function is slow, particularly in CKD-5 patients. Albuminuria and PTH at baseline levels are prognostic factors in the evolution of renal function.
YR 2016
FD 2016-11-05
LK http://hdl.handle.net/10668/10592
UL http://hdl.handle.net/10668/10592
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DS RISalud
RD Apr 12, 2025