TY  - JOUR
AU  - Entrenas Castillo, Marta
AU  - Entrenas Costa, Luis Manuel
AU  - Vaquero Barrios, José Manuel
AU  - Alcalá Díaz, Juan Francisco
AU  - López Miranda, José
AU  - Bouillon, Roger
AU  - Quesada Gomez, José Manuel
PY  - 2020
DO  - 0.1016/j.jsbmb.2020.105751
SN  - 0960-0760
UR  - http://hdl.handle.net/10668/3215
T2  - Journal of Steroid Biochemistry and Molecular Biology
AB  - Objective: The vitamin D endocrine system may have a variety of actions on cells and tissues involved in COVID-19 progression especially by decreasing the Acute Respiratory Distress Syndrome. Calcifediol can rapidly increase serum 25OHD concentration....
LA  - en
PB  - Elsevier Ltd.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - Vitamin D
KW  - Vitamin D3 or calcitriol
KW  - Calcifediol or 25-hydroxyvitamin D3
KW  - 1α, 25(OH)2D or 1α, 25-dihydroxyvitamin D or calcitriol
KW  - Acute respiratory distress syndrome (ARDS)
KW  - Cytokine/Chemokine storm
KW  - Renin-angiotensin system
KW  - Hypercoagulability
KW  - Hydroxychloroquine
KW  - Chloroquine
KW  - Covidiol
KW  - Neutrophil activity
KW  - Vitamin D endocrine system
KW  - Cuboidal alveolar coating cells type II
KW  - Cathelicidin peptide
KW  - Defensins
KW  - TLR co-receptor CD14
KW  - Vitamin D receptor
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Bone Density Conservation Agents
KW  - Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Secosteroids::Vitamin D::Cholecalciferol::Hydroxycholecalciferols::Calcifediol
KW  - Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Double-Blind Method
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Pilot Projects
KW  - Medical Subject Headings::Diseases::Respiratory Tract Diseases::Respiratory Tract Infections::Pneumonia
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
TI  - Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study.
TY  - research article
ER  -