RT Journal Article
T1 Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.
A1 Nedeljkovic, Ivana
A1 Carnero-Montoro, Elena
A1 Lahousse, Lies
A1 van der Plaat, Diana A
A1 de Jong, Kim
A1 Vonk, Judith M
A1 van Diemen, Cleo C
A1 Faiz, Alen
A1 van den Berge, Maarten
A1 Obeidat, Ma'en
A1 Bossé, Yohan
A1 Nickle, David C
A1 Consortium, Bios
A1 Uitterlinden, Andre G
A1 van Meurs, Joyce J B
A1 Stricker, Bruno C H
A1 Brusselle, Guy G
A1 Postma, Dirkje S
A1 Boezen, H Marike
A1 van Duijn, Cornelia M
A1 Amin, Najaf
AB Chronic obstructive pulmonary disease (COPD) is a major health burden in adults and cigarette smoking is considered the most important environmental risk factor of COPD. Chromosome 15q25.1 locus is associated with both COPD and smoking. Our study aims at understanding the mechanism underlying the association of chromosome 15q25.1 with COPD through epigenetic and transcriptional variation in a population-based setting. To assess if COPD-associated variants in 15q25.1 are methylation quantitative trait loci, epigenome-wide association analysis of four genetic variants, previously associated with COPD (P T-CHRNA3, rs8034191:T>C-HYKK, rs13180:C>T-IREB2 and rs8042238:C>T-IREB2), was performed in the Rotterdam study (n = 1489). All four variants were significantly associated (P C-HYKK, rs13180:C>T-IREB2 and rs8042238:C>T-IREB2), was performed in the Rotterdam study (n = 1489). All four variants were significantly associated (P T-IREB2 and rs8042238:C>T-IREB2), was performed in the Rotterdam study (n = 1489). All four variants were significantly associated (P T-IREB2), was performed in the Rotterdam study (n = 1489). All four variants were significantly associated (P 
YR 2018
FD 2018-02-08
LK http://hdl.handle.net/10668/12105
UL http://hdl.handle.net/10668/12105
LA en
DS RISalud
RD Apr 4, 2025