RT Journal Article
T1 Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets.
A1 Rojas, Ángela
A1 Del Campo, Jose A
A1 Clement, Sophie
A1 Lemasson, Matthieu
A1 García-Valdecasas, Marta
A1 Gil-Gómez, Antonio
A1 Ranchal, Isidora
A1 Bartosch, Birke
A1 Bautista, Juan D
A1 Rosenberg, Arielle R
A1 Negro, Francesco
A1 Romero-Gómez, Manuel
K1 Antivirales
K1 Diacilglicerol o-acetiltransferasa
K1 Genoma viral
K1 Hepacivirus
K1 Hepatitis C
K1 Quercetina
K1 Regulación hacia arriba
AB Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact mechanisms whereby quercetin impacts the HCV life cycle are not fully understood. We assessed the effect of quercetin on different steps of the HCV life cycle in Huh-7.5 cells and primary human hepatocytes (PHH) infected with HCVcc. In both cell types, quercetin significantly decreased i) the viral genome replication; ii) the production of infectious HCV particles and iii) the specific infectivity of the newly produced viral particles (by 85% and 92%, Huh7.5 and PHH respectively). In addition, when applied directly on HCV particles, quercetin reduced their infectivity by 65%, suggesting that it affects the virion integrity. Interestingly, the HCV-induced up-regulation of diacylglycerol acyltransferase (DGAT) and the typical localization of the HCV core protein to the surface of lipid droplets, known to be mediated by DGAT, were both prevented by quercetin. In conclusion, quercetin appears to have direct and host-mediated antiviral effects against HCV.
PB Thieme Publishing
YR 2016
FD 2016-08-22
LK http://hdl.handle.net/10668/2493
UL http://hdl.handle.net/10668/2493
LA en
NO Rojas Á, Del Campo JA, Clement S, Lemasson M, García-Valdecasas M, Gil-Gómez A, et al. Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets. Sci Rep. 2016                         ; 6:31777
NO Journal Article;
DS RISalud
RD Apr 16, 2025