RT Journal Article
T1 Risk factors differentially associated with non-alcoholic fatty liver disease in males and females with metabolic syndrome.
A1 Bullón Vela, María Vanessa
A1 Abete, Itziar
A1 Zulet, María de Los Ángeles
A1 Tur, Josep A
A1 Pintó, Xavier
A1 Corbella, Emili
A1 Martínez González, Miguel Ángel
A1 Corella, Dolores
A1 Macías González, Manuel
A1 Tinahones, Francisco
A1 Fitó, Montserrat
A1 Estruch, Ramón
A1 Ros, Emilio
A1 Salas Salvadó, Jordi
A1 Daimiel, Lidia
A1 Martínez, J Alfredo
AB non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries. This study aimed to investigate putative risk factors differentially related with NAFLD in obese males and females diagnosed with metabolic syndrome (MetS), stratified using the non-invasive hepatic steatosis index (HSI). a cross-sectional analysis of the PREDIMED Plus study was performed of 278 participants with MetS (141 males and 137 females) of the Navarra-Nutrition node. Subjects were categorized by HSI tertiles and gender. Baseline clinical, biochemical variants and adherence to a Mediterranean diet and physical activity were evaluated. multivariate analyses showed that females had 4.54 more units of HSI (95% CI: 3.41 to 5.68) than males. Both sexes showed increased levels of triglycerides, TG/HDL cholesterol ratio and triglyceride glucose index across the HSI tertiles. Physical activity exhibited a negative statistical association with HSI (males: r = -0.19, p = 0.025; females: r = -0.18, p = 0.031). The amount of visceral fat showed a positive association with HSI in both sexes (males: r = 0.64, p  females had a poor liver status, suggesting gender differences related to NAFLD. Adherence to a Mediterranean diet and physical activity were associated with beneficial effects on cardiovascular disease features. Thus, reducing the risk of hepatic steatosis in subjects with MetS and obesity.
SN 1130-0108
YR 2020
FD 2020
LK http://hdl.handle.net/10668/14887
UL http://hdl.handle.net/10668/14887
LA en
DS RISalud
RD Apr 7, 2025