TY - JOUR AU - De-Bus, Liesbet AU - Depuydt, Pieter AU - Steen, Johan AU - Dhaese, Sofie AU - De-Smet, Ken AU - Tabah, Alexis AU - Akova, Murat AU - Cotta, Menino Osbert AU - De-Pascale, Gennaro AU - Dimopoulos, George AU - Fujitani, Shigeki AU - Garnacho-Montero, Jose AU - Leone, Marc AU - Lipman, Jeffrey AU - Ostermann, Marlies AU - Paiva, José-Artur AU - Schouten, Jeroen AU - Sjövall, Fredrik AU - Timsit, Jean-François AU - Roberts, Jason A AU - Zahar, Jean-Ralph AU - Zand, Farid AU - Zirpe, Kapil AU - De-Waele, Jan J PY - 2020 DO - 10.1007/s00134-020-06111-5 UR - http://hdl.handle.net/10668/15716 T2 - Intensive care medicine AB - The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation. Adult ICU... LA - en PB - Springer KW - Antimicrobial de-escalation KW - Bacterial infection KW - Clinical cure KW - Empirical therapy KW - Intensive care unit KW - Adult KW - Anti-Bacterial Agents KW - Anti-Infective Agents KW - Carbapenems KW - Critical Illness KW - Humans KW - Intensive Care Units TI - Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study. TY - research article VL - 46 ER -