RT Journal Article
T1 Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients
A1 Gonzalez-Billalabeitia, Enrique
A1 Castellano, Daniel
A1 Sobrevilla, Nora
A1 Guma, Josep
A1 Hervas, David
A1 Luengo, Maria I.
A1 Aparicio, Jorge
A1 Sanchez-Munoz, Alfonso
A1 Mellado, Begona
A1 Saenz, Alberto
A1 Valverde, Claudia
A1 Fernandez, Antonio
A1 Margeli, Mireia
A1 Duran, Ignacio
A1 Fernandez, Sara
A1 Sastre, Javier
A1 Ros, Silverio
A1 Maroto, Pablo
A1 Manneh, Ray
A1 Cerezuela, Pablo
A1 Carmona-Bayonas, Alberto
A1 Spanish Germ Cell Canc Grp Grp Ger, 
K1 Cisplatin-based chemotherapy
K1 Risk
K1 Survival
K1 Tumors
AB Disseminated germ cell cancers are at high risk of developing thromboembolic complications. We evaluated the prognostic value of venous thromboembolic events (VTE) in disseminated germ cell cancer. Patients with germ cell cancer receiving upfront platinum-containing chemotherapy between 2004 and 2014 were pooled from the Spanish Germ Cell Cancer Group (SGCCG) registry and reviewed for the presence of VTE. Results were validated in an independent international group of patients. We used a penalized Cox proportional hazards model including VTE as a time-varying covariate to identify and validate prognostic factors. All statistical tests were two-sided. The SGCCG registry identified 416 patients from 14 referral institutions. With a median follow-up of 49 months, VTEs were observed in 9% of patients (n = 38). Events occurred at diagnosis, during chemotherapy, and after chemotherapy in 2.6%, 5.0%, and 1.4% of patients, respectively. VTE was associated with shorter progression-free survival (PFS; hazard ratio [HR] = 2.29, 95% confidence interval [CI] = 1.18 to 4.47, P = .02) and overall survival (OS; HR = 5.14, 95% CI = 2.22 to 11.88, P VTE is an independent adverse prognostic factor in disseminated germ cell cancers, in particular for the intermediate prognostic group of the International Germ Cell Cancer Collaborative Group classification. The presence of VTE at diagnosis has also prognostic significance and should be further explored in future prognostic classifications.
PB Oxford univ press inc
SN 0027-8874
YR 2017
FD 2017-04-01
LK http://hdl.handle.net/10668/18958
UL http://hdl.handle.net/10668/18958
LA en
DS RISalud
RD Apr 7, 2025