RT Journal Article
T1 Fucodendropeptides induce changes in cells of the immune system in food allergic patients via DC-SIGN receptor.
A1 Palomares, Francisca
A1 Gomez, Francisca
A1 de-la-Fuente, M Carmen
A1 Perez-Sanchez, Natalia
A1 Torres, Maria Jose
A1 Mayorga, Cristobalina
A1 Rojo, Javier
A1 Ramos-Soriano, Javier
K1 Click chemistry
K1 DC-SIGN
K1 Fucose
K1 Glycodendrimer
K1 Glycodendropeptide
K1 Pru p 3
AB Food allergy induced by lipid transfer proteins (LTPs) of Rosacea fruit family, such as peach, is becoming an important health problem in the Mediterranean area. Current treatments, such as allergen specific immunotherapy (AIT) with allergenic extracts show promising, but in many cases, they need an improvement in homogeneity, availability and induction of tolerant responses. Peptide-based vaccines containing adjuvants, such as carbohydrates for C-type lectin receptors (CLRs) are presented as an alternative approach. In this work, we have prepared fucosylated glycodendropeptides (GDPs) functionalized with Pru p 3 peptides via click chemistry. These GDPs, DnFuc9Prup3, induced changes in moDC maturation and lymphocyte proliferation in food allergic patients, indicating specific recognition via DC-SIGN receptor. From these data, D4Fuc9Prup3 can be considered a promising candidate for specific immunotherapy development.
PB Elsevier
YR 2022
FD 2022-05-06
LK http://hdl.handle.net/10668/22070
UL http://hdl.handle.net/10668/22070
LA en
NO Palomares F, Gomez F, de la Fuente MC, Perez-Sanchez N, Torres MJ, Mayorga C, et al. Fucodendropeptides induce changes in cells of the immune system in food allergic patients via DC-SIGN receptor. Carbohydr Res. 2022 Jul;517:108580
NO JRS thanks Junta de Andalucía for a Talent Hub Postdoctoral fellowship (DOC_00782). This research was funded by grant from MCIN/AEI/10.13039/501100011033 (PID2020-118403 GB-I00), ISCIII (PI18/00288) and RETICS ARADyAL (RD16/0006/0001 and RD16/ 0006/0011), Andalusian Regional Ministry of Health (PE-0039-2018 and PI-0099-2020), Senior Clinical Researcher Program (B-0005-2019), Nicolas Monardes Program (RC-0004-2021), Juan Rodes Program (JR21/00024) and Roche Pharma S.A. “Stop Fuga de Cerebros” Program (SFC-0002-2020). Grants were co-funded by the European Regional Development Fund (ERDF). “A way of making Europe” “Andalucía se mueve con Europa”.
DS RISalud
RD Apr 19, 2025