TY - JOUR AU - Dagg, Rebecca A AU - Zonderland, Gijs AU - Lombardi, Emilia Puig AU - Rossetti, Giacomo G AU - Groelly, Florian J AU - Barroso, Sonia AU - Tacconi, Eliana M C AU - Wright, Benjamin AU - Lockstone, Helen AU - Aguilera, Andrés AU - Halazonetis, Thanos D AU - Tarsounas, Madalena PY - 2021 DO - 10.1038/s41467-021-25215-0 UR - http://hdl.handle.net/10668/18372 T2 - Nature communications AB - BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour genomes revealed that oncogene amplification and BRCA1/2 mutations are mutually exclusive in cancer, however the molecular... LA - en KW - BRCA1 Protein KW - BRCA2 Protein KW - Breast Neoplasms KW - Cell Line, Tumor KW - Cell Proliferation KW - Cell Survival KW - Cells, Cultured KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DNA Damage KW - Female KW - Gene Expression Profiling KW - HeLa Cells KW - Humans KW - Oncogenes KW - Ovarian Neoplasms KW - RNA-Seq KW - Transcription, Genetic KW - beta Catenin TI - A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells. TY - research article VL - 12 ER -